[PDF][PDF] GA4GH: International policies and standards for data sharing across genomic research and healthcare
Summary The Global Alliance for Genomics and Health (GA4GH) aims to accelerate
biomedical advances by enabling the responsible sharing of clinical and genomic data …
biomedical advances by enabling the responsible sharing of clinical and genomic data …
Cardiovascular care innovation through data-driven discoveries in the electronic health record
The electronic health record (EHR) represents a rich source of patient information,
increasingly being leveraged for cardiovascular research. Although its primary use remains …
increasingly being leveraged for cardiovascular research. Although its primary use remains …
An overview of methodological flaws of real-world studies investigating drug safety in the post-marketing setting
Introduction The evaluation of the post-marketing safety profile of drugs is a continuous
monitoring process for approved and marketed medicines and it is crucial for detecting new …
monitoring process for approved and marketed medicines and it is crucial for detecting new …
Recommendations to overcome barriers to the use of artificial intelligence-driven evidence in health technology assessment
Background Artificial intelligence (AI) has attracted much attention because of its enormous
potential in healthcare, but uptake has been slow. There are substantial barriers that …
potential in healthcare, but uptake has been slow. There are substantial barriers that …
A natural language processing algorithm to improve completeness of ecog performance status in real-world data
Featured Application Critical clinical variables, such as ECOG performance status, are
required for retrospective research but may be incomplete. A natural language processing …
required for retrospective research but may be incomplete. A natural language processing …
Unraveling COVID-19: a large-scale characterization of 4.5 million COVID-19 cases using CHARYBDIS
Purpose Routinely collected real world data (RWD) have great utility in aiding the novel
coronavirus disease (COVID-19) pandemic response. Here we present the international …
coronavirus disease (COVID-19) pandemic response. Here we present the international …
The challenges of outcomes-based contract implementation for medicines in Europe
N Bohm, S Bermingham, F Grimsey Jones… - …, 2022 - Springer
Objectives The aim was to outline the challenges of implementing outcomes-based
contracts (OBCs) in Europe. Methods A scoping review was conducted, building on the …
contracts (OBCs) in Europe. Methods A scoping review was conducted, building on the …
From inception to ConcePTION: genesis of a network to support better monitoring and communication of medication safety during pregnancy and breastfeeding
NH Thurin, R Pajouheshnia, G Roberto… - Clinical …, 2022 - Wiley Online Library
In 2019, the Innovative Medicines Initiative (IMI) funded the ConcePTION project—Building
an ecosystem for better monitoring and communicating safety of medicines use in …
an ecosystem for better monitoring and communicating safety of medicines use in …
Target trial emulation for transparent and robust estimation of treatment effects for health technology assessment using real-world data: opportunities and challenges
Evidence about the relative effects of new treatments is typically collected in randomised
controlled trials (RCTs). In many instances, evidence from RCTs falls short of the needs of …
controlled trials (RCTs). In many instances, evidence from RCTs falls short of the needs of …
Using iterative pairwise external validation to contextualize prediction model performance: a use case predicting 1-year heart failure risk in patients with diabetes …
Introduction External validation of prediction models is increasingly being seen as a
minimum requirement for acceptance in clinical practice. However, the lack of …
minimum requirement for acceptance in clinical practice. However, the lack of …