The biology of Hepatocellular carcinoma: implications for genomic and immune therapies

G Khemlina, S Ikeda, R Kurzrock - Molecular cancer, 2017 - Springer
Hepatocellular carcinoma (HCC), the most common type of primary liver cancer, is a leading
cause of cancer-related death worldwide. It is highly refractory to most systemic therapies …

Roles and regulation of long noncoding RNAs in hepatocellular carcinoma

LJ Lim, SYS Wong, F Huang, S Lim, SS Chong, LL Ooi… - Cancer Research, 2019 - AACR
Next-generation sequencing has uncovered thousands of long noncoding RNAs (lncRNA).
Many are reported to be aberrantly expressed in various cancers, including hepatocellular …

The emerging role of long noncoding RNAs in human disease

JK DiStefano - Disease Gene Identification: Methods and Protocols, 2018 - Springer
Only a small fraction of the human genome corresponds to protein-coding genes.
Historically, the vast majority of genomic sequence was dismissed as transcriptionally silent …

A novel lncRNA uc. 134 represses hepatocellular carcinoma progression by inhibiting CUL4A-mediated ubiquitination of LATS1

W Ni, Y Zhang, Z Zhan, F Ye, Y Liang, J Huang… - Journal of hematology & …, 2017 - Springer
Background Hepatocellular carcinoma (HCC) is one of the most common malignancies
worldwide, and tumor recurrence and metastasis are major factors that contribute to the poor …

[HTML][HTML] Hepatocellular carcinoma: a comprehensive review of biomarkers, clinical aspects, and therapy

NM Tunissiolli, MMU Castanhole-Nunes… - Asian Pacific journal …, 2017 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is a cause of several deaths related to cancer worldwidely.
In early stage, curative treatments such as surgical resection, liver transplant and local …

Knockdown of lncRNA‑HOTAIR downregulates the drug‑resistance of breast cancer cells to doxorubicin via the PI3K/AKT/mTOR signaling pathway

Z Li, J Qian, J Li, C Zhu - Experimental and therapeutic …, 2019 - spandidos-publications.com
The resistance to chemotherapeutic drugs is a critical feature of breast cancer recurrence
and metastasis. Long non‑coding RNAs (LncRNAs) serve key roles in tumor drug …

Advancements in the diagnosis of hepatocellular carcinoma

NS Parra, HM Ross, A Khan, M Wu, R Goldberg… - International Journal of …, 2023 - mdpi.com
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy, with
increasing global incidence. Morbidity and mortality associated with HCC remains high, and …

Silencing of LncRNA-HOTAIR decreases drug resistance of non-small cell lung cancer cells by inactivating autophagy via suppressing the phosphorylation of ULK1

Y Yang, C Jiang, Y Yang, L Guo, J Huang, X Liu… - Biochemical and …, 2018 - Elsevier
Drug resistance is an important factor leading to the recurrence and metastasis of Non-Small
Cell Lung Cancer (NSCLC). Long non-coding RNAs (LncRNAs) play important roles in drug …

Accuracy of novel diagnostic biomarkers for hepatocellular carcinoma: An update for clinicians

P Reichl, W Mikulits - Oncology reports, 2016 - spandidos-publications.com
Hepatocellular carcinoma (HCC) is the most common liver malignancy and a leading cause
of cancer-related mortality worldwide. Accurate detection and differential diagnosis of early …

Identification of circulating long noncoding RNA HOTAIR as a novel biomarker for diagnosis and monitoring of non–small cell lung cancer

N Li, Y Wang, X Liu, P Luo, W Jing… - Technology in Cancer …, 2017 - journals.sagepub.com
Long noncoding RNA (LncRNA) homeotic genes (HOX) transcript antisense RNA (HOTAIR)
has been reported to play a vital role in various cancers. It has been found that HOTAIR was …