The ubiquitin proteasome system (UPS) is the main system for controlled protein
degradation and a key regulator of fundamental cellular processes. The dependency of …

Alterations in protein ubiquitylation and hypoxia are commonly associated with cancer.
Ubiquitylation is carried out by three sequentially acting ubiquitylating enzymes and can be …

To explore the biology of lung adenocarcinoma (LUAD) and identify new therapeutic
opportunities, we performed comprehensive proteogenomic characterization of 110 tumors …

Differential mRNA expression studies implicitly assume that changes in mRNA expression
have biological meaning, most likely mediated by corresponding changes in protein levels …

The ability of physicians to effectively treat and cure cancer is directly dependent on their
ability to detect cancers at their earliest stages. Proteomic analyses of early-stage cancers …

The sequencing of the human genome and that of numerous pathogens has opened the
door for proteomics by providing a sequence-based framework for mining proteomes. As a …

The eukaryotic initiation factor eIF5A is a translation factor that, unusually, has been
assigned functions in both initiation and elongation. Additionally, it is implicated in …

Motivation: Novel methods, both molecular and statistical, are urgently needed to take
advantage of recent advances in biotechnology and the human genome project for disease …

Tissue transglutaminase (TG2) is a widely distributed multifunctional protein involved in a
broad range of cellular and metabolic functions carried out in a variety of cellular …

1.1. Lung Cancer Cancer, one of the most life-threatening diseases, has more than 200
distinct types associated with it, affecting over 60 human organs. More than 90% of all …