Metabolites generated from cellular and tissue metabolism have been rediscovered in
recent years as signalling molecules. They may act as cofactor of enzymes or be linked to …

Whether under anaerobic or aerobic conditions, glycolysis results in production of lactate.
Increasing evidence suggests that lactate serves as a multifunctional signaling molecule that …

Lactate, the end product of glycolysis, efficiently functions as the carbon source, signaling
molecules and immune regulators. Lactylation, being regulated by lactate, has recently been …

In recent years, a significant breakthrough has emerged in biology, the identification of
lactylation, a novel post‐translational process. This intriguing modification is not limited to a …

Abstract Recently, lysine lactylation (Kla), a novel post-translational modification (PTM),
which can be stimulated by lactate, has been found to regulate gene expression and life …

Background Lactate is an important metabolite derived from glycolysis under physiological
and pathological conditions. The Warburg effect reveals the vital role of lactate in cancer …

L-Lactylation is a recently discovered post-translational modification occurring on histone
lysine residues to regulate gene expression. However, the substrate scope of lactylation …

As a major product of glycolysis and a vital signaling molecule, many studies have reported
the key role of lactate in tumor progression and cell fate determination. Lactylation is a newly …

Metabolites play important roles in numerous cell biology processes, such as cell
proliferation, differentiation, stress response, and cell death [1]. Recently, lactate and lactate …

For decades, lactate has been considered a byproduct of glycolysis. The lactate shuttle
hypothesis shifted the lactate paradigm, demonstrating that lactate not only plays important …