Advancing targeted protein degradation via multiomics profiling and artificial intelligence
M Duran-Frigola, M Cigler… - Journal of the American …, 2023 - ACS Publications
Only around 20% of the human proteome is considered to be druggable with small-molecule
antagonists. This leaves some of the most compelling therapeutic targets outside the reach …
antagonists. This leaves some of the most compelling therapeutic targets outside the reach …
Recent advances and challenges in protein structure prediction
Artificial intelligence has made significant advances in the field of protein structure prediction
in recent years. In particular, DeepMind's end-to-end model, AlphaFold2, has demonstrated …
in recent years. In particular, DeepMind's end-to-end model, AlphaFold2, has demonstrated …
MolAICal: a soft tool for 3D drug design of protein targets by artificial intelligence and classical algorithm
Deep learning is an important branch of artificial intelligence that has been successfully
applied into medicine and two-dimensional ligand design. The three-dimensional (3D) …
applied into medicine and two-dimensional ligand design. The three-dimensional (3D) …
COVID-19 Docking Server: A meta server for docking small molecules, peptides and antibodies against potential targets of COVID-19
R Kong, G Yang, R Xue, M Liu, F Wang, J Hu… - …, 2020 - academic.oup.com
Motivation The coronavirus disease 2019 (COVID-19) caused by a new type of coronavirus
has been emerging from China and led to thousands of death globally since December …
has been emerging from China and led to thousands of death globally since December …
In Silico Investigation on the Interaction of Chiral Phytochemicals from Opuntia ficus-indica with SARS-CoV-2 Mpro
C Vicidomini, V Roviello, GN Roviello - Symmetry, 2021 - mdpi.com
Opuntia ficus-indica is a cactaceous plant native to America but, nowadays, widely found
worldwide, having been the most common domesticated species of cactus grown as a crop …
worldwide, having been the most common domesticated species of cactus grown as a crop …
NLRP6 potentiates PI3K/AKT signalling by promoting autophagic degradation of p85α to drive tumorigenesis
F Zhi, B Li, C Zhang, F Xia, R Wang, W Xie… - Nature …, 2023 - nature.com
Abstract The PI3K/AKT pathway plays an essential role in tumour development. NOD-like
receptors (NLRs) regulate innate immunity and are implicated in cancer, but whether they …
receptors (NLRs) regulate innate immunity and are implicated in cancer, but whether they …
nCoVDock2: a docking server to predict the binding modes between COVID-19 targets and its potential ligands
The rapid emergence of SARS-CoV-2 variants with multi-sites mutations is considered as a
major obstacle for the development of drugs and vaccines. Although most of the functional …
major obstacle for the development of drugs and vaccines. Although most of the functional …
Evidence of protein binding by a nucleopeptide based on a thyminedecorated L-diaminopropanoic acid through CD and in silico studies
V Roviello, D Musumeci, A Mokhir… - Current Medicinal …, 2021 - ingentaconnect.com
Background: Nucleopeptides are chimeric compounds of biomedical importance carrying
DNA nucleobases anchored to peptide backbones with the ascertained capacity to bind …
DNA nucleobases anchored to peptide backbones with the ascertained capacity to bind …
Peptide modelling and screening against human ACE2 and spike glycoprotein RBD of SARS-CoV-2
SB Rathod, PB Prajapati, LB Punjabi, KN Prajapati… - In silico …, 2020 - Springer
Abstract Outbreak of Coronavirus Disease 2019 (COVID-19) has become a great challenge
for scientific community globally. Virus enters cell through spike glycoprotein fusion with …
for scientific community globally. Virus enters cell through spike glycoprotein fusion with …
[HTML][HTML] ADAM8 deficiency in macrophages promotes cardiac repair after myocardial infarction via ANXA2-mTOR-autophagy pathway
Z Ji, J Guo, R Zhang, W Zuo, Y Xu, Y Qu, Z Tao… - Journal of Advanced …, 2024 - Elsevier
Introduction A disintegrin and metalloproteinase 8 (ADAM8), a crucial regulator in
macrophages, is closely associated with cardiovascular disease progression. Objectives …
macrophages, is closely associated with cardiovascular disease progression. Objectives …