Bone remodeling is the continual process to renew the adult skeleton through the sequential
action of osteoblasts and osteoclasts. Nuclear factor RANK, an osteoclast receptor, and its …

Leptin is a critical mediator of the immune response to changes in overall nutrition. Leptin is
produced by adipocytes in proportion to adipose tissue mass and is therefore increased in …

Chronic energy deficiency can impair the hypothalamic-pituitary-gonadal (HPG) axis and
lead to hypothalamic anovulation in underweight women. This review presents the …

Leptin was initially best known for its role in energy homeostasis and regulation of energy
expenditure. In the past few years we have realized that leptin also plays a major role in …

Leptin is a master regulator of energy balance and body adiposity. Additionally, leptin exerts
important control on glucose homeostasis, thermogenesis, autonomic nervous system and …

Background: There is increasing evidence that changes in thyroid function are associated
with obesity, a condition associated with a chronic low-grade state of inflammation …

In 1968, Bruce McEwen discovered that 3 H-corticosterone administered to
adrenalectomised rats is retained in neurons of hippocampus rather than those of …

Leptin is an important regulator of basal metabolism and food intake, with a pivotal role in
obesity. Leptin exerts many different actions on various tissues and systems, including …

Leptin has central importance in the global obesity and cardiovascular disease problem.
Leptin is principally secreted by adipocytes and acts in the hypothalamus to suppress …

Leptin, a peptide hormone secreted by adipocytes, plays a central role in controlling appetite
and weight in both rodents and humans. Basic science and clinical research suggest that …