Milestone Review: Metabolic dynamics of glutamate and GABA mediated neurotransmission—The essential roles of astrocytes

JV Andersen, A Schousboe - Journal of Neurochemistry, 2023 - Wiley Online Library
Since it was first generally accepted that the two amino acids glutamate and GABA act as
principal neurotransmitters, several landmark discoveries relating to this function have been …

Astrocytic modulation of neuronal signalling

SS Purushotham, Y Buskila - Frontiers in Network Physiology, 2023 - frontiersin.org
Neuronal signalling is a key element in neuronal communication and is essential for the
proper functioning of the CNS. Astrocytes, the most prominent glia in the brain play a key …

A systematic review of the neuropathology and memory decline induced by monosodium glutamate in the Alzheimer's disease-like animal model

SS Ankul, L Chandran, S Anuragh… - Frontiers in …, 2023 - frontiersin.org
This systematic review analyzes monosodium glutamate (MSG) in the Alzheimer's disease-
like condition to enhance translational research. Our review seeks to understand how MSG …

An Expanded Narrative Review of Neurotransmitters on Alzheimer's Disease: The Role of Therapeutic Interventions on Neurotransmission

E Akyuz, A Arulsamy, FS Aslan, B Sarisözen… - Molecular …, 2024 - Springer
Alzheimer's disease (AD) is a progressive neurodegenerative disease. The accumulation of
amyloid-β (Aβ) plaques and tau neurofibrillary tangles are the key players responsible for …

The neurotransmitter puzzle of Alzheimer's: Dissecting mechanisms and exploring therapeutic horizons

M Sharma, P Pal, SK Gupta - Brain Research, 2024 - Elsevier
Alzheimer's Disease (AD) represents a complex interplay of neurological pathways and
molecular mechanisms, with significant impacts on patients' lives. This review synthesizes …

Gut microbiota metabolites: potential therapeutic targets for Alzheimer's disease?

S Zhang, J Lu, Z Jin, H Xu, D Zhang, J Chen… - Frontiers in …, 2024 - frontiersin.org
Background Alzheimer's disease (AD) is a neurodegenerative disease characterized by
progressive decline in cognitive function, which significantly increases pain and social …

Role of Astrocytes in Alzheimer's Disease Pathogenesis and the Impact of Exercise-Induced Remodeling

J Shao, Q Deng, S Feng, C Wu, X Liu, L Yang - … and biophysical research …, 2024 - Elsevier
Alzheimer's disease (AD) is a prevalent and debilitating brain disorder that worsens
progressively with age, characterized by cognitive decline and memory impairment. The …

Mechanisms of glutamate metabolic function and dysfunction in vascular dementia

J Wang, Y Zhang, N Tian, D Ya, J Yang… - …, 2024 - Wiley Online Library
As the global population ages, research on the pathogenesis and treatment options for older
patients with dementia has become increasingly important. Vascular dementia (VaD), the …

Glutamate and excitotoxicity in central nervous system disorders: ionotropic glutamate receptors as a target for neuroprotection

JY Magdaleno Roman, C Chapa González - Neuroprotection, 2024 - Wiley Online Library
Recent advances in neuroscience have illuminated the central role of glutamate
dysregulation in various neurological disorders. The glutamatergic system has emerged as …

Retinal Ganglion Cell Excitability and Adaptations to Ionic Stress in Glaucomatous Optic Neuropathy

A Boal - 2023 - ir.vanderbilt.edu
Neurodegenerative diseases are complex disorders that affect various regions and cells in
the central nervous system, sharing common hallmark features of progression. Intrinsic and …