Virulence factors of Leishmania parasite: Their paramount importance in unraveling novel vaccine candidates and therapeutic targets

D Kumari, S Mahajan, P Kour, K Singh - Life sciences, 2022 - Elsevier
Leishmaniasis is a neglected tropical disease and remains a global concern for healthcare.
It is caused by an opportunistic protozoan parasite belonging to the genus Leishmania and …

The immunological, environmental, and phylogenetic perpetrators of metastatic leishmaniasis

MA Hartley, S Drexler, C Ronet, SM Beverley… - Trends in …, 2014 - cell.com
Cutaneous leishmaniases have persisted for centuries as chronically disfiguring parasitic
infections affecting millions of people across the subtropics. Symptoms range from the more …

Leishmaniavirus-Dependent Metastatic Leishmaniasis Is Prevented by Blocking IL-17A

MA Hartley, E Bourreau, M Rossi, P Castiglioni… - PLoS …, 2016 - journals.plos.org
Cutaneous leishmaniasis has various outcomes, ranging from self-healing reddened
papules to extensive open ulcerations that metastasise to secondary sites and are often …

Protective or detrimental? understanding the role of host immunity in leishmaniasis

C dos Santos Meira, L Gedamu - Microorganisms, 2019 - mdpi.com
The intracellular protozoan parasites of the genus Leishmania are the causative agents of
leishmaniasis, a vector-borne disease of major public health concern, estimated to affect 12 …

Repurposing the antibacterial agents peptide 19-4LF and peptide 19-2.5 for treatment of cutaneous leishmaniasis

R El-Dirany, C Fernández-Rubio, J Peña-Guerrero… - Pharmaceutics, 2022 - mdpi.com
The lack of safe and cost-effective treatments against leishmaniasis highlights the urgent
need to develop improved leishmanicidal agents. Antimicrobial peptides (AMPs) are an …

Treatment of leishmaniasis: a review and assessment of recent research

E Kotb Elmahallawy, A Agil - Current pharmaceutical design, 2015 - ingentaconnect.com
Leishmaniasis is a diverse group of neglected diseases caused by protozoan parasite of
genus Leishmania and transmitted by the bite of a female phlebotomine sand fly. These …

Unveiling the intracellular survival gene kit of trypanosomatid parasites

DC Bartholomeu, RMC de Paiva, TAO Mendes… - PLoS …, 2014 - journals.plos.org
Trypanosomatids are unicellular protozoans of medical and economical relevance since
they are the etiologic agents of infectious diseases in humans as well as livestock. Whereas …

Nanoparticles as multifunctional devices for the topical treatment of cutaneous leishmaniasis

E Moreno, J Schwartz, C Fernandez… - Expert Opinion on …, 2014 - Taylor & Francis
Introduction: Cutaneous and mucocutaneous leishmaniasis are major tropical skin diseases.
Topical treatment is currently limited to the least severe forms of cutaneous leishmaniasis …

Influence of Leishmania RNA Virus 1 on Proinflammatory Biomarker Expression in a Human Macrophage Model of American Tegumentary Leishmaniasis

R Kariyawasam, J Grewal, R Lau… - The Journal of …, 2017 - academic.oup.com
Abstract Backgound Species of the Leishmania Viannia (LV) subgenus harbor the double-
stranded Leishmania RNA virus 1 (LRV-1), previously identified in isolates from Brazil and …

Topical simvastatin as host-directed therapy against severity of cutaneous leishmaniasis in mice

SP Parihar, MA Hartley, R Hurdayal, R Guler… - Scientific reports, 2016 - nature.com
We recently demonstrated that statins mediate protection against intracellular pathogens,
Mycobacterium tuberculosis and Listeria monocytogenes in mice. Here, we investigated the …