Human pluripotent stem cells (hPSCs) and three-dimensional organoids have ushered in a
new era for disease modeling and drug discovery. Over the past decade, significant …

Parkinson disease (PD) is a neurological movement disorder resulting primarily from
damage to and degeneration of the nigrostriatal dopaminergic pathway. The pathway …

SARS-CoV-2 has caused the COVID-19 pandemic. There is an urgent need for
physiological models to study SARS-CoV-2 infection using human disease-relevant cells …

Parkinson's disease (PD) is a complex neurodegenerative disease with etiology rooted in
genetic vulnerability and environmental factors. Here we combine quantitative …

Leukemia inhibitory factor (LIF), an indispensable bioactive protein that sustains self‐
renewal and pluripotency in stem cells, is vital for mouse embryonic stem cell (mESC) …

COVID-19 patients commonly present with signs of central nervous system and/or peripheral
nervous system dysfunction. Here, we show that midbrain dopamine (DA) neurons derived …

Persistent organic pollutants (POPs) are a diverse family of contaminants that show
widespread global dispersion and bioaccumulation. Humans are continuously exposed to …

Studies on diabetes have long been hampered by a lack of authentic disease models that,
ideally, should be unlimited and able to recapitulate the abnormalities involved in the …

Long noncoding RNAs (lncRNAs) are RNA molecules comprising more than 200
nucleotides, which are not translated into proteins. Many studies have shown that lncRNAs …

Exposure to environmental chemicals can impair neurodevelopment, and oligodendrocytes
may be particularly vulnerable, as their development extends from gestation into adulthood …