Background Lipopolysaccharide, a highly potent endotoxin responsible for severe sepsis, is
the major constituent of the outer membrane of gram-negative bacteria. Endothelial cells …

BACKGROUND In the Study of Tranexamic Acid During Air and Ground Prehospital
Transport (STAAMP) Trial, prehospital tranexamic acid (TXA) was associated with lower …

Background Optimal balance between macro-and microcirculation in critically ill patients is
crucial for ensuring optimal organ perfusion. Nitric oxide (NO) is a regulator of vascular …

Background Clarkson disease (monoclonal gammopathy-associated idiopathic systemic
capillary leak syndrome, ISCLS) is a rare idiopathic condition marked by transient, relapsing …

Sepsis is a major cause of death worldwide, with a mortality rate that has remained
stubbornly high. The current gold standard of risk stratifying sepsis patients provides limited …

Background Limited evidence exists regarding the link between platelet count and 30-day in-
hospital mortality in acute respiratory failure (ARF) patients. Thus, this study aims to …

Baseline levels of endotheliopathy are associated with worse respiratory outcomes and
mortality in undifferentiated acute respiratory failure (ARF), but knowledge is lacking on the …

Background Acute respiratory failure (ARF) is common in critically ill patients, and 50% of
patients in intensive care units require mechanical ventilation [3, 4]. The COVID‐19 …

目的探讨凝血酶-抗凝血酶复合物（ thrombin-antithrombin complex, TAT）、 纤溶酶-α 2
抗纤溶酶复合物（ plasmin-α 2-plasmin inhibitor complex, PIC）、 可溶性血栓调节蛋白（ soluble …

Objective To investigate the relationship between thrombin-antithrombin complex (TAT),
plasmin-α 2-plasmininhibitor complex (PIC), soluble thrombomodulin (sTM), and tissue …