Despite considerable progress in genome-and proteome-based high-throughput screening
methods and in rational drug design, the increase in approved drugs in the past decade did …

Single molecule and NMR measurements of protein dynamics increasingly uncover the
complexity of binding scenarios. Here, we describe an extended conformational selection …

Water is essential for life in many ways, and without it biomolecules might no longer truly be
biomolecules. In particular, water is important to the structure, stability, dynamics, and …

Despite considerable progress in genome-and proteome-based high-throughput screening
methods and rational drug design, the number of successful single-target drugs did not …

It is clear now that proteins lacking ordered structure, generally known as intrinsically
disordered proteins (IDPs), possess numerous biological functions that complement …

Proteins are constantly involved in the multitude of various interactions creating
sophisticated networks which define and control all (or almost all) the biological processes …

The network paradigm is increasingly used to describe the topology and dynamics of
complex systems. Here, we review the results of the topological analysis of protein structures …

Background The word selectivity describes a drug's ability to affect a particular cell
population in preference to others. As part of the current state of art in the search for new …

Protein folding is a spontaneous process that is essential for life, yet the concentrated and
complex interior of a cell is an inherently hostile environment for the efficient folding of many …

Knowledge of the relationship between protein's structure and its dynamic behavior is
essential for understanding protein function. In this study, the description of a protein three …