In the development of central nervous system (CNS) drugs, the blood–brain barrier (BBB)
restricts many drugs from entering the brain to exert therapeutic effects. Although many …

Small molecule drugs that covalently bind irreversibly to their target proteins have several
advantages over conventional reversible inhibitors. They include increased duration of …

In the field of drug discovery, the nitrile group is well represented among drugs and
biologically active compounds. It can form both non-covalent and covalent interactions with …

Cysteine proteases (CPs) are an important class of enzymes, many of which are responsible
for several human diseases. For instance, cruzain of protozoan parasite Trypanosoma cruzi …

Introduction With the increasing incidence and prevalence of neurological disorders
globally, there is a paramount need for new pharmacotherapies. BBB effectively protects the …

Peptidomimetics of the class of dipeptidyl nitrile analog peptoids were synthesized as
inhibitors of mammalian cysteine proteases of the papain superfamily. The dipeptidyl nitrile …

Toxoplasma gondii is the causative agent of toxoplasmosis, and an important problem of
public health. The current treatment for toxoplasmosis is the combination of pyrimethamine …

It is estimated that more than 2 billion people are chronically infected with the intracellular
protozoan parasite Toxoplasma gondii (T. gondii). Despite this, there is currently no vaccine …

The current treatments for toxoplasmosis are only active against fast-growing tachyzoites,
present in acute infections, with little effect on slow-growing bradyzoites within tissue cysts …

This study aimed to investigate the effect of rosuvastatin treatment on anxiety-related
behavior and short-and long-term memory impairment in mice infected with acute RH and …