Despite significant advancements, state-of-the-art care remains inaccessible to patients with
hemophilia, especially those from developing countries. Thus, innovative approaches in the …

Haemophilia A, the most common severe hereditary bleeding disorder in humans, is chiefly
caused by mutations in the coagulation factor VIII F8 gene, which maps on chromosome …

Our 25 years of experience in carrier diagnosis of hemophilia A (HA) and B (HB) in Mexican
population comprises linkage analysis of intragenic F8/F9 neutral variants along with, in …

Hemophilia A is an X‐linked, inherited, bleeding disorder caused by the partial or total
inactivity of the coagulation factor VIII (FVIII). Due to difficulties in the direct recognition of the …

Hemophilia A (HA) is the most common inherited X‑linked recessive bleeding disorder
caused by heterogeneous mutations in the factor VIII gene (FVIII). Diagnosis of the carrier is …

Objective: To screen Haemophilia-A patients for five known recurrent F8 gene variants and
to analyze CA repeats in intron 13 of F8 gene in the mother and the affected child pairs …

Indirect linkage analysis using highly informative polymorphic markers is the method of
choice for carrier detection of hemophilia A in developing countries because direct DNA or …

Background: Indirect genetic diagnosis using polymorphic DNA markers can detect carriers
of hemophilia A. This technique is preferable in developing countries because of its …

Background: Hemophilia A is an X-linked recessively inherited bleeding disorder
characterized by deficiency of pro-coagulant factor VIII (FVIII). Genetic diagnosis is the most …

زمینه و هدف: هموفیلی A یک اختلال خون‌ریزی دهنده وابسته به جنس مغلوب است که به علت جهش‌های
گوناگون در ژن فاکتور ٨ که پروتئین انعقادی فاکتور 8 را کد می‌کند، رخ می‌دهد. با توجه به درجه …‎