Traditional drug development and discovery has not kept pace with threats from emerging
and re-emerging diseases such as Ebola virus, MERS-CoV and more recently, SARS-CoV …

ONC201 was originally discovered as TNF-Related Apoptosis Inducing Ligand (TRAIL)-
inducing compound TIC10. ONC201 appears to act as a selective antagonist of the G …

Cancer progression involves the gradual loss of a differentiated phenotype and acquisition
of progenitor and stem-cell-like features. Here, we provide novel stemness indices for …

Abstract Knowledge of the underpinnings of cancer initiation, progression and metastasis
has increased exponentially in recent years. Advanced “omics” coupled with machine …

Large-scale perturbation databases, such as Connectivity Map (CMap) or Library of
Integrated Network-based Cellular Signatures (LINCS), provide enormous opportunities for …

Abstract Dopamine (DA, 3-hydroxytyramine) is a member of the catecholamine family and is
classically characterized according to its role in the central nervous system as a …

Phenothiazines have been used in many areas of medicine, mainly in psychopharmacology.
These compounds are able to effectively inhibit dopamine, histamine, serotonin …

Thioridazine (THD) is a common phenothiazine antipsychotic drug reported to suppress
growth in several types of cancer cells. We previously showed that THD acts as an …

Glioblastoma multiforme (GBM) is the most malignant primary adult brain tumor. The current
standard of care is surgical resection, radiation, and chemotherapy treatment, which extends …

Multidrug resistance (MDR) is a major obstacle in the therapy of infectious diseases and
cancer. One of the major mechanisms of MDR is the overexpression of efflux pumps (EPs) …