A comparative and evolutionary approach to oxidative stress in fish: a review

K Birnie‐Gauvin, D Costantini, SJ Cooke… - Fish and …, 2017 - Wiley Online Library
Oxidative stress results from an imbalance between the production of reactive oxygen
species and the antioxidants defences, in favour of the former. In recent years, the …

Glutathione homeostasis and functions: potential targets for medical interventions

VI Lushchak - Journal of amino acids, 2012 - Wiley Online Library
Glutathione (GSH) is a tripeptide, which has many biological roles including protection
against reactive oxygen and nitrogen species. The primary goal of this paper is to …

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

EL Mills, DG Ryan, HA Prag, D Dikovskaya, D Menon… - Nature, 2018 - nature.com
The endogenous metabolite itaconate has recently emerged as a regulator of macrophage
function, but its precise mechanism of action remains poorly understood,,. Here we show …

Thioredoxins, glutaredoxins, and peroxiredoxins—molecular mechanisms and health significance: from cofactors to antioxidants to redox signaling

EM Hanschmann, JR Godoy, C Berndt… - Antioxidants & redox …, 2013 - liebertpub.com
Abstract Thioredoxins (Trxs), glutaredoxins (Grxs), and peroxiredoxins (Prxs) have been
characterized as electron donors, guards of the intracellular redox state, and “antioxidants” …

Glutathione: overview of its protective roles, measurement, and biosynthesis

HJ Forman, H Zhang, A Rinna - Molecular aspects of medicine, 2009 - Elsevier
This review is the introduction to a special issue concerning, glutathione (GSH), the most
abundant low molecular weight thiol compound synthesized in cells. GSH plays critical roles …

Invited review: oxidation of biological systems: oxidative stress phenomena, antioxidants, redox reactions, and methods for their quantification

R Kohen, A Nyska - Toxicologic pathology, 2002 - journals.sagepub.com
Reactive oxygen species (ROS) and other radicals are involved in a variety of biological
phenomena, such as mutation, carcinogenesis, degenerative and other diseases …

Analysis of GSH and GSSG after derivatization with N-ethylmaleimide

D Giustarini, I Dalle-Donne, A Milzani, P Fanti… - Nature protocols, 2013 - nature.com
This protocol describes a procedure for determining glutathione (GSH) and glutathione
disulfide (GSSG) concentrations in blood and other tissues. Artifactual oxidation to GSSG of …

Gastroprotective effect of sinapic acid on ethanol-induced gastric ulcers in rats: involvement of Nrf2/HO-1 and NF-κB signaling and antiapoptotic role

M Raish, M Shahid, YA Bin Jardan… - Frontiers in …, 2021 - frontiersin.org
Background: In the current study, we evaluated the therapeutic potential of sinapic acid (SA)
in terms of the mechanism underlying its gastroprotective action against ethanol-induced …

Mitigation of systemic oxidative stress by curcuminoids in osteoarthritis: results of a randomized controlled trial

Y Panahi, GH Alishiri, S Parvin… - Journal of dietary …, 2016 - Taylor & Francis
Oxidative stress is implicated in the pathogenesis of osteoarthritis. Curcuminoids are natural
polyphenols with strong antioxidant capacity and may thus be helpful in the treatment of …

Glutathione, glutathione-dependent and antioxidant enzymes in mussel, Mytilus galloprovincialis, exposed to metals under field and laboratory conditions …

F Regoli, G Principato - Aquatic toxicology, 1995 - Elsevier
The effects of exposure to metals under and laboratory conditions were investigated in the
Mediterranean mussel Mytilus galloprovincialis. The examined biological responses …