Krüppel-like factors: crippling and uncrippling metabolic pathways

NM Pollak, M Hoffman, IJ Goldberg… - JACC: Basic to …, 2018 - jacc.org
Krüppel-like factors (KLFs) are deoxyribonucleic acid–binding transcriptional factors that
regulate various pathways that control metabolism and other cellular mechanisms. Various …

EKLF/KLF1, a tissue-restricted integrator of transcriptional control, chromatin remodeling, and lineage determination

YY Yien, JJ Bieker - Molecular and cellular biology, 2013 - Am Soc Microbiol
Erythroid Krüppel-like factor (EKLF or KLF1) is a transcriptional regulator that plays a critical
role in lineage-restricted control of gene expression. KLF1 expression and activity are tightly …

Maternal diet alters long-term innate immune cell memory in fetal and juvenile hematopoietic stem and progenitor cells in nonhuman primate offspring

MJ Nash, E Dobrinskikh, TK Soderborg, RC Janssen… - Cell reports, 2023 - cell.com
Maternal overnutrition increases inflammatory and metabolic disease risk in postnatal
offspring. This constitutes a major public health concern due to increasing prevalence of …

Eosinophil function in adipose tissue is regulated by Krüppel-like factor 3 (KLF3)

AJ Knights, EJ Vohralik, PJ Houweling, ES Stout… - Nature …, 2020 - nature.com
The conversion of white adipocytes to thermogenic beige adipocytes represents a potential
mechanism to treat obesity and related metabolic disorders. However, the mechanisms …

KLF1 directly activates expression of the novel fetal globin repressor ZBTB7A/LRF in erythroid cells

LJ Norton, APW Funnell, J Burdach, B Wienert… - Blood …, 2017 - ashpublications.org
Genes encoding the human β-like hemoglobin proteins undergo a developmental switch
from fetal γ-globin to adult β-globin expression around the time of birth. β …

MiR‐326/Sp1/KLF3: A novel regulatory axis in lung cancer progression

R Wang, J Xu, J Xu, W Zhu, T Qiu, J Li… - Cell …, 2019 - Wiley Online Library
Objectives To investigate the function and regulatory mechanism of Krüppel‐like factor 3
(KLF3) in lung cancer. Materials and Methods KLF3 expression was analysed by qRT‐PCR …

Krüppel-like factors compete for promoters and enhancers to fine-tune transcription

MD Ilsley, KR Gillinder, GW Magor… - Nucleic acids …, 2017 - academic.oup.com
Krüppel-like factors (KLFs) are a family of 17 transcription factors characterized by a
conserved DNA-binding domain of three zinc fingers and a variable N-terminal domain …

PRKCE non-coding variants influence on transcription as well as translation of its gene

K Khan, S Zafar, A Hafeez, Y Badshah, K Shahid… - RNA biology, 2022 - Taylor & Francis
Untranslated regions of the gene play a crucial role in gene expression regulation at mRNA
and protein levels. Mutations at UTRs impact expression by altering transcription factor …

Transcriptional mechanisms underlying hemoglobin synthesis

KR Katsumura, AW DeVilbiss… - Cold Spring …, 2013 - perspectivesinmedicine.cshlp.org
The physiological switch in expression of the embryonic, fetal, and adult β-like globin genes
has garnered enormous attention from investigators interested in transcriptional …

Loss of Krüppel-like factor 3 (KLF3/BKLF) leads to upregulation of the insulin-sensitizing factor adipolin (FAM132A/CTRP12/C1qdc2)

KS Bell-Anderson, AP Funnell, H Williams… - Diabetes, 2013 - Am Diabetes Assoc
Krüppel-like factor 3 (KLF3) is a transcriptional regulator that we have shown to be involved
in the regulation of adipogenesis in vitro. Here, we report that KLF3-null mice are lean and …