Hypoxia and inflammation are frequently co-incidental features of the tissue
microenvironment in a wide range of inflammatory diseases. While the impact of hypoxia on …

The complex cross‐talk of intricate intercellular signaling networks between the tumor and
stromal cells promotes cancer progression. Hypoxia is one of the most common conditions …

This study aimed to analyze the therapeutic effect of Rhein on ulcerative colitis (UC) in mice
and its possible mechanism. LPS‐induced UC cell model and DSS‐induced UC mouse …

Inflammatory bowel diseases (IBD), encompassing Crohn's disease (CD) and ulcerative
colitis (UC), are intimately associated with inflammation and overproduction of reactive …

Inflammatory bowel disease (IBD) is a complex multifactorial disease of unknown etiology.
Thus, dozens of different animal models of IBD have been developed in past decades …

Hypoxia-inducible factors (HIFs) are stabilized during adverse inflammatory processes
associated with disorders such as inflammatory bowel disease, pathogen infection and …

Macrophages are present throughout the human body, constitute important immune effector
cells, and have variable roles in a great number of pathological, but also physiological …

Hypoxia-inducible factor (HIF) is an important transcriptional regulator of cell metabolism
and the adaptation to cellular stress caused by oxygen deficiency (hypoxia). Phagocytic …

The unique anatomy and physiology of the intestine in conjunction with its microbial content
create the steepest oxygen gradients in the body, which plunge to near anoxia at the luminal …

The colonic epithelium can undergo multiple rounds of damage and repair, often in
response to excessive inflammation. The responsive stem cell that mediates this process is …