Targeting adenosine in cancer immunotherapy to enhance T-cell function

S Vigano, D Alatzoglou, M Irving… - Frontiers in …, 2019 - frontiersin.org
T cells play a critical role in cancer control, but a range of potent immunosuppressive
mechanisms can be upregulated in the tumor microenvironment (TME) to abrogate their …

Extracellular purines, purinergic receptors and tumor growth

F Di Virgilio, E Adinolfi - Oncogene, 2017 - nature.com
Virtually, all tumor cells as well as all immune cells express plasma membrane receptors for
extracellular nucleosides (adenosine) and nucleotides (ATP, ADP, UTP, UDP and sugar …

Immunity, inflammation and cancer: a leading role for adenosine

L Antonioli, C Blandizzi, P Pacher, G Haskó - Nature Reviews Cancer, 2013 - nature.com
Cancer is a complex disease that is dictated by both cancer cell-intrinsic and cell-extrinsic
processes. Adenosine is an ancient extracellular signalling molecule that can regulate …

Adenosine receptors: expression, function and regulation

S Sheth, R Brito, D Mukherjea, LP Rybak… - International journal of …, 2014 - mdpi.com
Adenosine receptors (ARs) comprise a group of G protein-coupled receptors (GPCR) which
mediate the physiological actions of adenosine. To date, four AR subtypes have been …

ADORA1 inhibition promotes tumor immune evasion by regulating the ATF3-PD-L1 axis

H Liu, X Kuang, Y Zhang, Y Ye, J Li, L Liang, Z Xie… - Cancer cell, 2020 - cell.com
Here, we show that tumor ADORA1 deletion suppresses cell growth in human melanoma
cell lines in vitro and tumor development in vivo in immune-deficient xenografts. However …

Extracellular adenosine triphosphate and adenosine in cancer

J Stagg, MJ Smyth - Oncogene, 2010 - nature.com
Adenosine triphosphate (ATP) is actively released in the extracellular environment in
response to tissue damage and cellular stress. Through the activation of P2X and P2Y …

Purinergic signalling and cancer

G Burnstock, F Di Virgilio - Purinergic signalling, 2013 - Springer
Receptors for extracellular nucleotides are widely expressed by mammalian cells. They
mediate a large array of responses ranging from growth stimulation to apoptosis, from …

[HTML][HTML] Adenosine receptors and cancer

S Gessi, S Merighi, V Sacchetto, C Simioni… - Biochimica et Biophysica …, 2011 - Elsevier
Adenosine is a ubiquitous signaling molecule whose physiological functions are mediated
by its interaction with four G-protein-coupled receptor subtypes, termed A1, A2A, A2B and …

Pharmacology of adenosine receptors: Recent advancements

F Vincenzi, S Pasquini, C Contri, M Cappello, M Nigro… - Biomolecules, 2023 - mdpi.com
Adenosine receptors (ARs) are widely acknowledged pharmacological targets yet are still
underutilized in clinical practice. Their ubiquitous distribution in almost all cells and tissues …

Adenosine and adenosine receptors in the immunopathogenesis and treatment of cancer

MH Kazemi, S Raoofi Mohseni… - Journal of Cellular …, 2018 - Wiley Online Library
Tumor cells overcome anti‐tumor responses in part through immunosuppressive
mechanisms. There are several immune modulatory mechanisms. Among them, adenosine …