Substance use in adolescence is a known risk factor for the development of neuropsychiatric
and substance use disorders in adulthood. This is in part due to the fact that critical aspects …

Addiction is a leading cause of disease burden worldwide and remains a challenge in
current neuroscience research. Drug-induced lasting changes in gene expression are …

Importance Although perceived as relatively harmless and nonaddictive, adolescent
cannabis use significantly increases the likelihood of developing cannabis use disorder in …

Rationale The endocannabinoid system makes critical contributions to reward processing,
motivation, and behavioral control. Repeated exposure to THC or other cannabinoid drugs …

Although chronic cannabis use during adolescence can alter brain function and impair
complex behavioral processes, it is unclear whether such deficits persist into adulthood …

Several studies performed on human subjects have examined the effects of adolescent
cannabis consumption on brain structure or function using brain imaging techniques …

Drug addiction is a leading cause of disability worldwide, with more than 70,000 Americans
dying from drug overdose in 2019 alone. While only a small percentage of chronic drug …

Drug exposure during adolescence, when the “reward” circuitry of the brain is developing,
can permanently impact reward-related behavior into adulthood. Epidemiological studies …

Evolutionarily conserved, peer-directed social behaviors are essential to participate in many
aspects of human society. These behaviors directly impact psychological, physiological, and …

Background Exposure to Δ 9-tetrahydrocannabinol (THC) is an established risk factor for
later-life neuropsychiatric vulnerability, including mood-and anxiety-related symptoms. The …