Genus flavivirus comprises many important human pathogens causing public health
problems worldwide. Some flavivirus infections are characterized by a relatively high …

Two different species of flaviviruses, dengue virus (DENV) and yellow fever virus (YFV), that
originated in sylvatic cycles maintained in non-human primates and forest-dwelling …

Abstract In Africa, Old World Primates are involved in the maintenance of sylvatic circulation
of ZIKV. However, in Brazil, the hosts for the sylvatic cycle remain unknown. We …

In the context of the only available vaccine (DENGVAXIA) that was marketed in several
countries, but poses higher risks to unexposed individuals, the development of antivirals for …

Zika virus (ZIKV) infection during pregnancy causes severe developmental defects in
newborns, termed congenital Zika syndrome (CZS). Factors contributing to a surge in ZIKV …

The development of a compelling murine model of dengue virus (DENV) infection has been
challenging, because DENV clinical isolates do not readily replicate or cause pathology in …

Abstract Development of a suitable animal model for dengue virus disease is critical for
understanding pathogenesis and for preclinical testing of antiviral drugs and vaccines. Many …

Dengue, a rapidly spreading mosquito-borne human viral disease caused by dengue virus
(DENV), is a public health concern in tropical and subtropical areas due to its expanding …

Marmosets are becoming more utilized in biomedical research due to multiple advantages
including (1) a nonhuman primate of a smaller size with less cost for housing,(2) physiologic …

Vertebrate interferon-induced transmembrane (IFITM) genes have been demonstrated to
have extensive and diverse functions, playing important roles in the evolution of vertebrates …