[HTML][HTML] Genome-wide association studies in ancestrally diverse populations: opportunities, methods, pitfalls, and recommendations
Genome-wide association studies (GWASs) have focused primarily on populations of
European descent, but it is essential that diverse populations become better represented …
European descent, but it is essential that diverse populations become better represented …
Comprehensive evaluation of mapping complex traits in wheat using genome-wide association studies
Genome-wide association studies (GWAS) are effectively applied to detect the marker trait
associations (MTAs) using whole genome-wide variants for complex quantitative traits in …
associations (MTAs) using whole genome-wide variants for complex quantitative traits in …
Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains
Attention-deficit hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder
with a major genetic component. Here, we present a genome-wide association study meta …
with a major genetic component. Here, we present a genome-wide association study meta …
Model-free estimation of recent genetic relatedness
MP Conomos, AP Reiner, BS Weir… - The American Journal of …, 2016 - cell.com
Genealogical inference from genetic data is essential for a variety of applications in human
genetics. In genome-wide and sequencing association studies, for example, accurate …
genetics. In genome-wide and sequencing association studies, for example, accurate …
Robust inference of population structure for ancestry prediction and correction of stratification in the presence of relatedness
Population structure inference with genetic data has been motivated by a variety of
applications in population genetics and genetic association studies. Several approaches …
applications in population genetics and genetic association studies. Several approaches …
Genetic diversity and association studies in US Hispanic/Latino populations: applications in the Hispanic Community Health Study/Study of Latinos
MP Conomos, CA Laurie, AM Stilp, SM Gogarten… - The American Journal of …, 2016 - cell.com
US Hispanic/Latino individuals are diverse in genetic ancestry, culture, and environmental
exposures. Here, we characterized and controlled for this diversity in genome-wide …
exposures. Here, we characterized and controlled for this diversity in genome-wide …
[HTML][HTML] Recommendations on the use and reporting of race, ethnicity, and ancestry in genetic research: Experiences from the NHLBI TOPMed program
How race, ethnicity, and ancestry are used in genomic research has wide-ranging
implications for how research is translated into clinical care and incorporated into public …
implications for how research is translated into clinical care and incorporated into public …
Conceptual approaches to the study of health disparities
AV Diez Roux - Annual review of public health, 2012 - annualreviews.org
Scientific and policy interest in health disparities, defined as systematic, plausibly avoidable
health differences adversely affecting socially disadvantaged groups, has increased …
health differences adversely affecting socially disadvantaged groups, has increased …
Illumina human exome genotyping array clustering and quality control
With the rise of high-throughput sequencing technology, traditional genotyping arrays are
gradually being replaced by sequencing technology. Against this trend, Illumina has …
gradually being replaced by sequencing technology. Against this trend, Illumina has …
Beyond SNP heritability: Polygenicity and discoverability of phenotypes estimated with a univariate Gaussian mixture model
Estimating the polygenicity (proportion of causally associated single nucleotide
polymorphisms (SNPs)) and discoverability (effect size variance) of causal SNPs for human …
polymorphisms (SNPs)) and discoverability (effect size variance) of causal SNPs for human …