The crystal structures of three Src-family tyrosine kinases have been determined recently.
The structure of the catalytic domain of Lck has been determined in the active …

The development of anti-virals has blunted the AIDS epidemic in the Western world but
globally the epidemic has not been curtailed. Standard vaccines have not worked, and …

The effect of C-terminal tyrosine phosphorylation on molecular motions in the Src kinases
Hck and c-Src is investigated by molecular dynamics simulations. The SH2 and SH3 …

Heterotrimeric G proteins transduce signals from cell surface receptors to modulate the
activity of cellular effectors. Src, the product of the first characterized proto-oncogene and the …

Gene expression profiling was used to explore the role of Nef in HIV. Nef induces a
transcriptional program in T cells that is 97% identical to that of anti-CD3 T cell activation …

Signal transducer and activator of transcription 5 (STAT5) is constitutively activated by
BCR/ABL, the oncogenic tyrosine kinase responsible for chronic myelogenous leukemia …

Nef of primate lentiviruses is critical for high levels of viremia and the progression to AIDS.
Nef associates with and activates a serine/threonine kinase (Nef-associated kinase [NAK]) …

Activation of the superoxide-producing phagocyte NADPH oxidase requires interaction
between p47 phox and p22 phox, which is mediated via the SH3 domains of the former …

The Vav family is a group of signal transduction molecules with oncogenic potential that play
important roles in development and cell signaling. Members of this family are distributed in …

Src-family kinases are modular signaling proteins involved in a diverse array of cellular
processes. All members of the Src family share the same domain organization, with modular …