Current approaches and challenges for the metabolite profiling of complex natural extracts

JL Wolfender, G Marti, A Thomas, S Bertrand - Journal of Chromatography …, 2015 - Elsevier
Metabolite profiling is critical in many aspects of the life sciences, particularly natural product
research. Obtaining precise information on the chemical composition of complex natural …

Fungal–fungal co-culture: a primer for generating chemical diversity

SL Knowles, HA Raja, CD Roberts… - Natural Product …, 2022 - pubs.rsc.org
Covering: 2002 to 2020 In their natural environment, fungi must compete for resources. It
has been hypothesized that this competition likely induces the biosynthesis of secondary …

Metabolite induction via microorganism co-culture: a potential way to enhance chemical diversity for drug discovery

S Bertrand, N Bohni, S Schnee, O Schumpp… - Biotechnology …, 2014 - Elsevier
Microorganisms have a long track record as important sources of novel bioactive natural
products, particularly in the field of drug discovery. While microbes have been shown to …

Microbial communication leading to the activation of silent fungal secondary metabolite gene clusters

T Netzker, J Fischer, J Weber, DJ Mattern… - Frontiers in …, 2015 - frontiersin.org
Microorganisms form diverse multispecies communities in various ecosystems. The high
abundance of fungal and bacterial species in these consortia results in specific …

Dereplication strategies in natural product research: How many tools and methodologies behind the same concept?

J Hubert, JM Nuzillard, JH Renault - Phytochemistry Reviews, 2017 - Springer
The development of new drugs will certainly benefit from an ever improving knowledge of
the living beings chemistry. However, identification of drugable molecules within the …

Dereplication: racing to speed up the natural products discovery process

SP Gaudêncio, F Pereira - Natural product reports, 2015 - pubs.rsc.org
Covering: 1993–2014 (July) To alleviate the dereplication holdup, which is a major
bottleneck in natural products discovery, scientists have been conducting their research …

From genomics to metabolomics, moving toward an integrated strategy for the discovery of fungal secondary metabolites

T Hautbergue, EL Jamin, L Debrauwer, O Puel… - Natural Product …, 2018 - pubs.rsc.org
Fungal secondary metabolites are defined by bioactive properties that ensure adaptation of
the fungus to its environment. Although some of these natural products are promising …

Expanding the chemical diversity through microorganisms co-culture: Current status and outlook

D Arora, P Gupta, S Jaglan, C Roullier, O Grovel… - Biotechnology …, 2020 - Elsevier
Natural products (NPs) are considered as a cornerstone for the generation of bioactive leads
in drug discovery programs. However, one of the major limitations of NP drug discovery …

Extraction for metabolomics: access to the metabolome

MY Mushtaq, YH Choi, R Verpoorte… - Phytochemical …, 2014 - Wiley Online Library
Introduction The value of information obtained from a metabolomic study depends on how
much of the metabolome is present in analysed samples. Thus, only a comprehensive and …

Enhancing chemical and biological diversity by co-cultivation

DM Selegato, I Castro-Gamboa - Frontiers in microbiology, 2023 - frontiersin.org
In natural product research, microbial metabolites have tremendous potential to provide new
therapeutic agents since extremely diverse chemical structures can be found in the nearly …