Endogenous opiates and behavior: 2022
RJ Bodnar - Peptides, 2023 - Elsevier
This paper is the forty-fifth consecutive installment of the annual anthological review of
research concerning the endogenous opioid system, summarizing articles published during …
research concerning the endogenous opioid system, summarizing articles published during …
Historical perspectives and recent advances in small molecule ligands of selective/biased/multi-targeted μ/δ/κ opioid receptor (2019–2022)
Y He, Q Su, L Zhao, L Zhang, L Yu, J Shi - Bioorganic Chemistry, 2023 - Elsevier
The opioids have been used for more than a thousand years and are not only the most
widely prescribed drugs for moderate to severe pain and acute pain, but also the preferred …
widely prescribed drugs for moderate to severe pain and acute pain, but also the preferred …
Discovery of a potent highly biased MOR partial agonist among diastereomeric C9-hydroxyalkyl-5-phenylmorphans
JA Lutz, A Sulima, ES Gutman, EW Bow, D Luo… - Molecules, 2023 - mdpi.com
All possible diastereomeric C9-hydroxymethyl-, hydroxyethyl-, and hydroxypropyl-
substituted 5-phenylmorphans were synthesized to explore the three-dimensional space …
substituted 5-phenylmorphans were synthesized to explore the three-dimensional space …
[HTML][HTML] Effects of selective and mixed-action kappa and delta opioid receptor agonists on pain-related behavioral depression in mice
SS Negus, CM St. Onge, YK Lee, M Li, KC Rice… - Molecules, 2024 - mdpi.com
We recently developed a series of nalfurafine analogs (TK10, TK33, and TK35) that may
serve as non-addictive candidate analgesics. These compounds are mixed-action agonists …
serve as non-addictive candidate analgesics. These compounds are mixed-action agonists …
Systematic Structure–Activity Relationship Study of Nalfurafine Analogues toward Development of Potentially Nonaddictive Pain Management Treatments
CM St. Onge, PP Pagare, Y Zheng… - Journal of Medicinal …, 2024 - ACS Publications
Despite the availability of numerous pain medications, the current array of Food and Drug
Administration-approved options falls short in adequately addressing pain states for …
Administration-approved options falls short in adequately addressing pain states for …
NCP, a dual kappa and mu opioid receptor agonist, is a potent analgesic against inflammatory pain without reinforcing or aversive properties
P Huang, CK Ho, D Cao, S Inan, SM Rawls, M Li… - … of Pharmacology and …, 2024 - ASPET
While agonists of μ (MOR) and κ (KOR) opioid receptors have analgesic effects, they
produce euphoria and dysphoria, respectively. Other side effects include respiratory …
produce euphoria and dysphoria, respectively. Other side effects include respiratory …
A straightforward trifluoromethylation at the C6 position of morphinane alkaloids, their modification and evaluation of inhibition of the SARS-CoV-2 main protease
AO Finke, VI Krasnov, TV Rybalova… - Journal of Fluorine …, 2023 - Elsevier
A catalytic trifluoromethylation of stereoisomeric 6-ketomorphinans using Ruppert–Prakash
reagent and tetrabutylammonium fluoride (TBAF) was studied. 14β-Hydroxycodeinone, 4-O …
reagent and tetrabutylammonium fluoride (TBAF) was studied. 14β-Hydroxycodeinone, 4-O …