More than 80 different adenovirus (AdV) types infect humans through the respiratory, ocular,
or gastrointestinal tracts. They cause acute clinical mani-festations or persist under humoral …

Oncolytic viruses (OVs) are an emerging treatment option for many cancer types and have
recently been the focus of extensive research aiming to develop their therapeutic potential …

Colorectal cancer (CRC) has the third highest incidence and the second highest mortality in
the world, which seriously affects human health, while current treatments methods for CRC …

Among human species B adenovirus, HAdV-11, has the particular feature of exploiting two
primary receptors, desmoglein 2 (DSG2) and CD46, to mediate cell attachment. This …

Enadenotucirev is an oncolytic group B adenovirus identified by a process of bio-selection
for the ability to selectively propagate in and rapidly kill carcinoma cells. It is resistant to …

Ionising radiation causes cell death through the induction of DNA damage, particularly
double-stranded DNA (dsDNA) breaks. Evidence suggests that adenoviruses inhibit …

Background Oncolytic viruses are currently experiencing accelerated development in
several laboratories worldwide, with some forty-seven clinical trials currently recruiting …

Colorectal cancer is the third most common neoplasm in the world and the third leading
cause of cancer-related deaths in the USA. A safer and more effective therapeutic …

Oncolytic viruses represent an emerging approach to cancer therapy. However, better
understanding of their interaction with the host cancer cell and approaches to enhance their …

In the present study, a series of forty-five asymmetrical meta-methoxylated diarylpentanoids
have been synthesized, characterized and evaluated for their in-vitro anti-cancer potential …