Dietary and physiological effects of zinc on the immune system

I Wessels, HJ Fischer, L Rink - Annual review of nutrition, 2021 - annualreviews.org
Evidence for the importance of zinc for all immune cells and for mounting an efficient and
balanced immune response to various environmental stressors has been accumulating in …

The SLC39 family of zinc transporters

J Jeong, DJ Eide - Molecular aspects of medicine, 2013 - Elsevier
Zinc is a trace element nutrient that is essential for life. This mineral serves as a cofactor for
enzymes that are involved in critical biochemical processes and it plays many structural …

Mammalian zinc transporters: nutritional and physiologic regulation

LA Lichten, RJ Cousins - Annual review of nutrition, 2009 - annualreviews.org
Research advances defining how zinc is transported into and out of cells and organelles
have increased exponentially within the past five years. Research has progressed through …

Current understanding of ZIP and ZnT zinc transporters in human health and diseases

T Kambe, A Hashimoto, S Fujimoto - Cellular and molecular life sciences, 2014 - Springer
Abstract Zinc transporters, the Zrt-, Irt-like protein (ZIP) family and the Zn transporter (ZnT)
family transporters, are found in all aspects of life. Increasing evidence has clarified the …

Genome-wide association study identifies loci affecting blood copper, selenium and zinc

DM Evans, G Zhu, V Dy, AC Heath… - Human molecular …, 2013 - academic.oup.com
Genetic variation affecting absorption, distribution or excretion of essential trace elements
may lead to health effects related to sub-clinical deficiency. We have tested for allelic effects …

Toward unzipping the ZIP metal transporters: structure, evolution, and implications on drug discovery against cancer

J Hu - The FEBS journal, 2021 - Wiley Online Library
The Zrt‐/Irt‐like protein (ZIP) family consists of divalent metal transporters, ubiquitous in all
kingdoms of life. Since the discovery of the first ZIPs in the 1990s, the ZIP family has been …

Zinc transporter ZIP14 functions in hepatic zinc, iron and glucose homeostasis during the innate immune response (endotoxemia)

T Beker Aydemir, SM Chang, GJ Guthrie, AB Maki… - PloS one, 2012 - journals.plos.org
ZIP14 (slc39A14) is a zinc transporter induced in response to pro-inflammatory stimuli.
ZIP14 induction accompanies the reduction in serum zinc (hypozincemia) of acute …

The molecular basis for zinc bioavailability

AG Hall, JC King - International journal of molecular sciences, 2023 - mdpi.com
Zinc is an essential micronutrient, and its deficiency is perhaps the most prevalent and least
understood worldwide. Recent advances have expanded the understanding of zinc's unique …

Gastrointestinal factors influencing zinc absorption and homeostasis

RJ Cousins - International Journal for Vitamin and Nutrition …, 2010 - econtent.hogrefe.com
Diet-derived luminal factors have a major inffuence on zinc available for uptake across the
apical membrane of enterocytes. Malabsorption and possibly intestinal microbiota limit this …

Zinc homeostasis and regulation: Zinc transmembrane transport through transporters

S Yin, M Duan, B Fang, G Zhao, X Leng… - Critical Reviews in …, 2023 - Taylor & Francis
The second abundant micronutrient, zinc, is attracting more and more attention for it
performs essential functions in living organisms and bears close relationships with the …