Receptor tyrosine kinase signalling pathways have been successfully targeted to inhibit
proliferation and angiogenesis for cancer therapy. However, kinase deregulation has been …

Ribosomal protein S6 (RPS6) is a component of the 40S small ribosomal subunit and
participates in the control of mRNA translation. Additionally, phospho (p)-RPS6 has been …

Hyperphosphorylation of the C-terminal domain (CTD) of the RPB1 subunit of human RNA
polymerase (Pol) II is essential for transcriptional elongation and mRNA processing,–. The …

The C-terminal domain (CTD) of the large subunit of RNA polymerase (pol) II comprises
conserved heptad repeats, and post-translational modification of the CTD regulates …

Formation of skeletal muscle fibers (myogenesis) during development and after tissue injury
in the adult constitutes an excellent paradigm to investigate the mechanisms whereby …

Inorganic polyphosphate (polyP) is a linear polymer of orthophosphate that is present in
nearly all organisms studied to date. A remarkable function of polyP involves its attachment …

The dosage of the serine threonine kinase DYRK1A is critical in the central nervous system
(CNS) during development and aging. This review analyzes the functions of this kinase by …

Massively parallel reporter assays (MPRAs) enable nucleotide-resolution dissection of
transcriptional regulatory regions, such as enhancers, but only few regions at a time. Here …

DYRK1A is a serine/threonine kinase encoded on human chromosome 21 (HSA21) that has
been implicated in several pathologies of Down syndrome (DS), including cognitive deficits …

Down syndrome (DS) is one of the leading causes of intellectual disability, and patients with
DS face various health issues, including learning and memory deficits, congenital heart …