Therapies for patients with cancer have changed gradually over the past decade, moving
away from the administration of broadly acting cytotoxic drugs towards the use of more …

Hormone signaling is important in a number of disease states, and hormone receptors are
effective therapeutic targets. PGRMC1 (progesterone receptor membrane component 1) is a …

We describe studies in molecular profiling and biological pathway analysis that use sparse
latent factor and regression models for microarray gene expression data. We discuss breast …

Affymetrix U133plus2 GeneChips were used to profile 59 head and neck squamous cell
cancers. A hypoxia metagene was obtained by analysis of genes whose in vivo expression …

Background Colon cancer has been classically described by clinicopathologic features that
permit the prediction of outcome only after surgical resection and staging. Methods We …

To better understand the role of transcription factor NF-E2-related factor (NRF) 2 in the
human and its contribution to cancer chemoprevention, we have knocked down its negative …

Multigene assays have been developed and validated to determine the prognosis of breast
cancer. In this study, we assessed the additional predictive value of the 70-gene …

Model search in regression with very large numbers of candidate predictors raises
challenges for both model specification and computation, for which standard approaches …

Dasatinib is a multitargeted kinase inhibitor that was recently approved for the treatment of
chronic myelogenous leukemia and Philadelphia chromosome–positive acute lymphoblastic …

Purpose: To identify molecular markers of pathologic response to neoadjuvant
paclitaxel/radiation treatment, protein and gene expression profiling were done on …