Application of amorphous solid dispersions (ASDs) is considered one of the most promising
approaches to increase the dissolution rate and extent of bioavailability of poorly water …

Current therapy of tuberculosis (TB) has several limitations, such as risk of liver injury and
intestinal dysbiosis due to frequent oral administration of antibiotics. Transdermal …

The objective of the study was to identify the extragranular component requirements (level
and type of excipients) to develop an immediate release tablet of solid dispersions prepared …

The purpose of the present study was to investigate the effect of polyethylene glycol (PEG)
molecular weights (6000, 12000 and 20000) as solid dispersion (SD) carriers on the …

Objective The main scope of the present investigation was to improve the bioavailability of
perphenazine (PPZ) by incorporating it into the nanostructured lipid carriers (NLCs) …

Objective. Perphenazine (PPZ), as a typical antipsychotic medical substance, has the same
effectiveness compared to atypical antipsychotic medications for the treatment of …

The aim of this study was to investigate the effects of solid dispersions (SD) and self-
emulsifying (SE) formulations on the solubility and absorption properties of active …

The aim of this contribution is to examine the impact of incorporating surfactants into
amorphous solid dispersions on solid state miscibility and aqueous solubility of the …

Disintegrating agents are excipients routinely included in tablet formulations and in some
hard shell capsule formulations to promote moisture penetration and dispersion of the matrix …

Background Perphenazine (PPZ) is a typical antipsychotic that is mainly administrated for
the treatment of schizophrenia. Due to its highly lipophilic nature and extensive hepatic first …