c-Kit, a receptor tyrosine kinase, is involved in intracellular signaling, and the mutated form
of c-Kit plays a crucial role in occurrence of some cancers. The function of c-Kit has led to the …

Cancer is one of the diseases with high morbidity and mortality on a global scale.
Chemotherapy remains the primary treatment option for most cancer patients, including …

With the development of targeted therapeutics, especially for small-molecule inhibitors, it is
important to understand whether the observed in vivo efficacy correlates with the modulation …

Metastatic disease is the principal cause of prostate-cancer-related mortality. Our ability to
accurately recapitulate the spread of prostate cancer to bone—the most common site of …

Human erythropoiesis is a complex multistep developmental process that begins at the level
of pluripotent hematopoietic stem cells (HSCs) at bone marrow microenvironment (HSCs …

Background c-Kit is a receptor tyrosine kinase present in multiple cell types, including
vascular smooth muscle cells (SMC). However, little is known about how c-Kit influences …

Cancer stem cells (CSC) are thought to be responsible for tumor initiation and tumor
regeneration after chemotherapy. Previously, we showed that chemotherapy of non–small …

ENMD-2076 is a novel orally active, small molecule kinase inhibitor with a mechanism of
action involving several pathways key to tumor growth and survival: angiogenesis …

The cancer stem cell hypothesis has been put forward as a paradigm to describe varying
levels of aggressiveness in heterogeneous tumors. Specifically, many subpopulations have …

Purpose: Gain-of-function mutations and KIT overexpression are well-known tumorigenesis
mechanisms in gastrointestinal stromal tumors (GIST). This study aimed to discover …