[HTML][HTML] Recent advances in the development of 17beta-hydroxysteroid dehydrogenase inhibitors
D Poirier - Steroids, 2024 - Elsevier
The family of 17β-hydroxysteroid dehydrogenases (17β-HSDs) occupies a prominent place
due to its number of isoforms, which carry out a bidirectional transformation (reduction of a …
due to its number of isoforms, which carry out a bidirectional transformation (reduction of a …
Discovery of an Aldo-Keto reductase 1C3 (AKR1C3) degrader
AV Carmona, S Jonnalagadda, AM Case… - Communications …, 2024 - nature.com
Abstract Aldo-keto reductase 1C3 (AKR1C3) is a protein upregulated in prostate cancer,
hematological malignancies, and other cancers where it contributes to proliferation and …
hematological malignancies, and other cancers where it contributes to proliferation and …
Coumarin‐Based Aldo‐Keto Reductase Family 1C (AKR1C) 2 and 3 Inhibitors
SK Jonnalagadda, L Duan, LF Dow… - …, 2024 - Wiley Online Library
A series of 7‐substituted coumarin derivatives have been characterized as pan‐aldo‐keto
reductase family 1C (AKR1C) inhibitors. The AKR1C family of enzymes are overexpressed …
reductase family 1C (AKR1C) inhibitors. The AKR1C family of enzymes are overexpressed …