Flavones: An important scaffold for medicinal chemistry
Flavones have antioxidant, anti-proliferative, anti-tumor, anti-microbial, estrogenic, acetyl
cholinesterase, anti-inflammatory activities and are also used in cancer, cardiovascular …
cholinesterase, anti-inflammatory activities and are also used in cancer, cardiovascular …
17β-Hydroxysteroid dehydrogenases (17β-HSDs) as therapeutic targets: protein structures, functions, and recent progress in inhibitor development
S Marchais-Oberwinkler, C Henn, G Möller… - The Journal of steroid …, 2011 - Elsevier
17β-Hydroxysteroid dehydrogenases (17β-HSDs) are oxidoreductases, which play a key
role in estrogen and androgen steroid metabolism by catalyzing final steps of the steroid …
role in estrogen and androgen steroid metabolism by catalyzing final steps of the steroid …
黄酮类化合物生理活性及合成研究进展
延玺， 刘会青， 邹永青， 任占华 - 有机化学, 2008 - sioc-journal.cn
摘要黄酮类化合物是一类植物次生代谢产物, 广泛存在于多种植物中, 不仅数量种类繁多,
而且结构类型复杂多样. 黄酮类化合物因其独特的化学结构而对哺乳动物和其它类型的细胞具有 …
而且结构类型复杂多样. 黄酮类化合物因其独特的化学结构而对哺乳动物和其它类型的细胞具有 …
[图书][B] Bioactive heterocyclic compound classes: agrochemicals
C Lamberth, J Dinges - 2012 - Wiley Online Library
Approximately 70% of all the 2400 pharmaceuticals listed in the online version of
''Pharmaceutical Substances''(A. Kleemann et al., Thieme) bear at least one heterocyclic …
''Pharmaceutical Substances''(A. Kleemann et al., Thieme) bear at least one heterocyclic …
The biological potential of flavones
AK Verma, R Pratap - Natural product reports, 2010 - pubs.rsc.org
Covering: 1990 to 2009 Flavones are well known for their antioxidant activity, and are
unique in that they are present in the majority of fruits and vegetables. The majority of …
unique in that they are present in the majority of fruits and vegetables. The majority of …
Recent Advances in the Synthesis of Heterocyclics via Cascade Cyclization of Propargylic Alcohols
XR Song, R Yang, Q Xiao - Advanced Synthesis & Catalysis, 2021 - Wiley Online Library
Heterocyclic compounds are important organic compounds and have emerged as key
scaffolds in numerous drugs, natural products, vitamins, biologically and pharmaceutically …
scaffolds in numerous drugs, natural products, vitamins, biologically and pharmaceutically …
Ruthenium (II)-catalyzed C–H activation of chromones with maleimides to synthesize succinimide/maleimide-containing chromones
Y Zhou, H Liang, Y Sheng, S Wang, Y Gao… - The Journal of …, 2020 - ACS Publications
An efficient route for the coupling of maleimides with chromones at the C5-position has been
developed under Ru (II) catalysis. It could provide 1, 4-addition products and oxidative Heck …
developed under Ru (II) catalysis. It could provide 1, 4-addition products and oxidative Heck …
Synthesis and structure–activity relationship of 1-and 2-substituted-1, 2, 3-triazole letrozole-based analogues as aromatase inhibitors
J Doiron, R Richard, MM Touré, N Picot… - European journal of …, 2011 - Elsevier
A series of bis-and mono-benzonitrile or phenyl analogues of letrozole 1, bearing (1, 2, 3
and 1, 2, 5)-triazole or imidazole, were synthesized and screened for their anti-aromatase …
and 1, 2, 5)-triazole or imidazole, were synthesized and screened for their anti-aromatase …
Combating breast cancer with non-steroidal aromatase inhibitors (NSAIs): Understanding the chemico-biological interactions through comparative SAR/QSAR study
It is a challenging task to design target-specific and less toxic non-steroidal aromatase
inhibitors (NSAIs) though the modeling studies for designing anti-aromatase molecules have …
inhibitors (NSAIs) though the modeling studies for designing anti-aromatase molecules have …
Design, synthesis, and biological evaluation of imidazolyl derivatives of 4, 7-disubstituted coumarins as aromatase inhibitors selective over 17-α-hydroxylase/C17− 20 …
A Stefanachi, AD Favia, O Nicolotti… - Journal of medicinal …, 2011 - ACS Publications
The design, synthesis, and biological evaluation of a series of new aromatase (AR, CYP19)
inhibitors bearing an imidazole ring linked to a 7-substituted coumarin scaffold at position 4 …
inhibitors bearing an imidazole ring linked to a 7-substituted coumarin scaffold at position 4 …