Fatigue is one of the most common symptoms in multiple sclerosis (MS), with a major impact
on patients' quality of life. Currently, treatment proceeds by trial and error with limited …

It is of considerable translational importance whether depression is a form or a consequence
of sickness behavior. Sickness behavior is a behavioral complex induced by infections and …

There is now evidence that depression, as characterized by melancholic symptoms, anxiety,
and fatigue and somatic (F&S) symptoms, is the clinical expression of peripheral cell …

Central noradrenergic (NA) signaling is broadly implicated in behavioral and physiological
processes related to attention, arousal, motivation, learning and memory, and homeostasis …

In multiple sclerosis (MS) patients, fatigue is rated as one of the most common and disabling
symptoms. However, the pathophysiology underlying this fatigue is not yet clear. Several …

The compensatory approach of fatigue argues that it is a state caused by task load. The
neuropsychiatric approach argues that fatigue is a trait (like depression), unrelated to …

Interactions between the nervous system and immune system have been studied
extensively. However, the mechanisms underlying the neural regulation of immune activity …

Studies have revealed that anti‐inflammatory agents could provide beneficial effect in
lowering the incidence/progression of neurological diseases. Hence, this study sought to …

Infection negatively impacts mental health, as evidenced by the lethargy, malaise, and
cognitive deficits experienced during illness. These changes in central nervous system …

Neural circuits distributed within the brainstem, hypothalamus, and limbic forebrain interact
to control food intake and energy balance under normal day-to-day conditions, and in …