The capability of carbohydrate utilization in fish is limited compared to mammals. It has
scientific and practical significance to improve the ability of fish to use carbohydrates. The …

The zebrafish is a model organism that allows in vivo studies to be performed at a scale
usually restricted to in vitro studies. As such, the zebrafish is well suited to in vivo screens, in …

Pancreatic β-cells form highly connected networks within isolated islets. Whether this
behaviour pertains to the situation in vivo, after innervation and during continuous perfusion …

The establishment of a functional cardiovascular system is crucial for the development of all
vertebrates. Defects in the development of the cardiovascular system lead to cardiovascular …

Regenerating pancreatic β-cells is a potential curative approach for diabetes. We previously
identified the small molecule CID661578 as a potent inducer of β-cell regeneration, but its …

Aims/hypothesis Recovering functional beta cell mass is a promising approach for future
diabetes therapies. The aim of the present study is to investigate the effects of adjudin, a …

The development of the cardiac outflow tract (OFT), which connects the heart to the great
arteries, relies on a complex crosstalk between endothelial (ECs) and smooth muscle …

An early step in pancreas development is marked by the expression of the transcription
factor Pdx1 within the pancreatic endoderm, where it is required for the specification of all …

Transcription factors including pregnane X receptor (Pxr) and nuclear factor-erythroid 2-
related factor-2 (Nrf2) are important modulators of Adenosine triphosphate-binding cassette …

Tight regulation of blood glucose is essential for long term health. Blood glucose levels are
defended by the correct function of, and communication between, internal organs including …