Approved antiviral drugs over the past 50 years

E De Clercq, G Li - Clinical microbiology reviews, 2016 - Am Soc Microbiol
Since the first antiviral drug, idoxuridine, was approved in 1963, 90 antiviral drugs
categorized into 13 functional groups have been formally approved for the treatment of the …

Therapeutic potential of flavonoids and their mechanism of action against microbial and viral infections—A review

A Ahmad, M Kaleem, Z Ahmed, H Shafiq - Food Research International, 2015 - Elsevier
Flavonoids are polyphenolic phytochemicals generally found in vegetables, fruits, flowers,
nuts, seeds, tea, honey and propolis. In the past plants containing these compounds have …

Second European evidence-based consensus on the prevention, diagnosis and management of opportunistic infections in inflammatory bowel disease

JF Rahier, F Magro, C Abreu, A Armuzzi… - Journal of Crohn's …, 2014 - academic.oup.com
6.1. Background The incidence of tuberculosis (TB) is a concern at the start of the third
millennium, particularly with the increase of multiresistant (MDR-TB) and extended resistant …

European evidence-based Consensus on the prevention, diagnosis and management of opportunistic infections in inflammatory bowel disease

JF Rahier, S Ben-Horin, Y Chowers… - Journal of Crohn's …, 2009 - academic.oup.com
The treatment of inflammatory bowel disease (IBD) has been revolutionised over the past
decade by the increasing use of immunomodulators, mainly azathioprine (AZA)/6 …

Human cytomegalovirus entry into epithelial and endothelial cells depends on genes UL128 to UL150 and occurs by endocytosis and low-pH fusion

BJ Ryckman, MA Jarvis, DD Drummond… - Journal of …, 2006 - Am Soc Microbiol
Human cytomegalovirus (HCMV) replication in epithelial and endothelial cells appears to be
important in virus spread, disease, and persistence. It has been difficult to study infection of …

Characterization of the human cytomegalovirus gH/gL/UL128-131 complex that mediates entry into epithelial and endothelial cells

BJ Ryckman, BL Rainish, MC Chase, JA Borton… - Journal of …, 2008 - Am Soc Microbiol
The entry of human cytomegalovirus (HCMV) into biologically relevant epithelial and
endothelial cells involves endocytosis followed by low-pH-dependent fusion. This entry …

The intracellular DNA sensor IFI16 gene acts as restriction factor for human cytomegalovirus replication

GR Gariano, V Dell'Oste, M Bronzini, D Gatti… - PLoS …, 2012 - journals.plos.org
Human interferon (IFN)-inducible IFI16 protein, an innate immune sensor of intracellular
DNA, modulates various cell functions, however, its role in regulating virus growth remains …

Association between viral infections and risk of autistic disorder: an overview

AN Shuid, PA Jayusman, N Shuid, J Ismail… - International journal of …, 2021 - mdpi.com
Autism spectrum disorder (ASD) is a neurodevelopmental condition of the central nervous
system (CNS) that presents with severe communication problems, impairment of social …

Where do we stand after decades of studying human cytomegalovirus?

F Gugliesi, A Coscia, G Griffante, G Galitska… - Microorganisms, 2020 - mdpi.com
Human cytomegalovirus (HCMV), a linear double-stranded DNA betaherpesvirus belonging
to the family of Herpesviridae, is characterized by widespread seroprevalence, ranging …

Cis and trans acting factors involved in human cytomegalovirus experimental and natural latent infection of CD14 (+) monocytes and CD34 (+) cells

CC Rossetto, M Tarrant-Elorza, GS Pari - PLoS pathogens, 2013 - journals.plos.org
The parameters involved in human cytomegalovirus (HCMV) latent infection in CD14 (+) and
CD34 (+) cells remain poorly identified. Using next generation sequencing we deduced the …