Histone deacetylases (HADC) are the enzymes that remove acetyl group from lysine residue
of histones and non-histone proteins and regulate the process of transcription by binding to …

Spinal muscular atrophy (SMA) is currently classified into five different subtypes, from the
most severe (type 0) to the mildest (type 4) depending on age at onset, best motor function …

Objective Assessment of SMN2 copy number in patients with spinal muscular atrophy (SMA)
is essential to establish careful genotype-phenotype correlations and predict disease …

Spinal muscular atrophy (SMA) is the most common genetic disease affecting infants and
young adults. Due to mutation/deletion of the survival motor neuron (SMN) gene, SMA is …

Genetic testing for SMA diagnosis, newborn screening, and carrier screening has become a
significant public health interest worldwide, driven largely by the development of novel and …

Background and purpose Spinal muscular atrophy (SMA) is the most important cause of
motor neuron disease in childhood, and continues to represent the leading genetic cause of …

Spinal muscular atrophy (SMA) is an autosomal recessive condition that results in
pathological deficiency of the survival motor neuron (SMN) protein. SMA most frequently …

Neuroinflammation plays a pathogenic role in neurodegenerative diseases and recent
findings suggest that it may also be involved in X-linked Dystonia-Parkinsonism (XDP) …

Spinal muscular atrophy (SMA) is a motor neuron disease and the leading genetic cause of
infant mortality. Recently approved SMA therapies have transformed a deadly disease into a …

Background and Objectives Spinal muscular atrophy (SMA) is a progressive neuromuscular
disorder associated with continuous motor function loss and complications, such as scoliosis …