The emerging mechanisms and functions of microautophagy

L Wang, DJ Klionsky, HM Shen - Nature reviews Molecular cell biology, 2023 - nature.com
Abstract 'Autophagy'refers to an evolutionarily conserved process through which cellular
contents, such as damaged organelles and protein aggregates, are delivered to lysosomes …

Lysosome biology in autophagy

WWY Yim, N Mizushima - Cell discovery, 2020 - nature.com
Autophagy is a major intracellular degradation system that derives its degradative abilities
from the lysosome. The most well-studied form of autophagy is macroautophagy, which …

GAPDH controls extracellular vesicle biogenesis and enhances the therapeutic potential of EV mediated siRNA delivery to the brain

GH Dar, CC Mendes, WL Kuan, AA Speciale… - Nature …, 2021 - nature.com
Extracellular vesicles (EVs) are biological nanoparticles with important roles in intercellular
communication, and potential as drug delivery vehicles. Here we demonstrate a role for the …

Restoring Oat Nanoparticles Mediated Brain Memory Function of Mice Fed Alcohol by Sorting Inflammatory Dectin‐1 Complex Into Microglial Exosomes

F Xu, J Mu, Y Teng, X Zhang, K Sundaram… - Small, 2022 - Wiley Online Library
Microglia modulate pro‐inflammatory and neurotoxic activities. Edible plant‐derived factors
improve brain function. Current knowledge of the molecular interactions between edible …

Nucleolin: a cell portal for viruses, bacteria, and toxins

F Tonello, ML Massimino, C Peggion - Cellular and Molecular Life …, 2022 - Springer
The main localization of nucleolin is the nucleolus, but this protein is present in multiple
subcellular sites, and it is unconventionally secreted. On the cell surface, nucleolin acts as a …

Autophagy modulators in cancer therapy

K Buzun, A Gornowicz, R Lesyk, K Bielawski… - International Journal of …, 2021 - mdpi.com
Autophagy is a process of self-degradation that plays an important role in removing
damaged proteins, organelles or cellular fragments from the cell. Under stressful conditions …

Regulation of macrophage cell surface GAPDH alters LL-37 internalization and downstream effects in the cell

A Dhiman, S Talukdar, GK Chaubey… - Journal of Innate …, 2023 - karger.com
Abstract Mycobacterium tuberculosis (M. tb), the major causative agent of tuberculosis, has
evolved mechanisms to evade host defenses and persist within host cells. Host-directed …

Biomaterial-enabled 3D cell culture technologies for extracellular vesicle manufacturing

J Johnston, T Stone, Y Wang - Biomaterials Science, 2023 - pubs.rsc.org
Extracellular vesicles (EVs) are lipid-based particles naturally released from cells and
recognized as promising drug delivery vehicles for improving therapeutic outcomes. Efficient …

Autophagy in the immunosuppressive perivascular microenvironment of glioblastoma

ML Molina, D García-Bernal, S Martinez, R Valdor - Cancers, 2019 - mdpi.com
Glioblastoma (GB) has been shown to up-regulate autophagy with anti-or pro-oncogenic
effects. Recently, our group has shown how GB cells aberrantly up-regulate chaperone …

High-resolution secretome analysis of chemical hypoxia treated cells identifies putative biomarkers of chondrosarcoma

DP Spanò, S Bonelli, M Calligaris, AP Carreca… - Proteomes, 2022 - mdpi.com
Chondrosarcoma is the second most common bone tumor, accounting for 20% of all cases.
Little is known about the pathology and molecular mechanisms involved in the development …