Abstract 17β‐Estradiol (E2), as the main circulating estrogen hormone, regulates many
tissue and organ functions in physiology. The effects of E2 on cells are mediated by the …

Estrogen receptors alpha (ERα) and beta (ERβ) are nuclear transcription factors that are
involved in the regulation of many complex physiological processes in humans. Modulation …

Estrogen receptors alpha (ERα) and beta (ERβ) are transcription factors that are involved in
the regulation of many complex physiological processes in humans. Abnormal ER signaling …

Current standard-of-care (SOC) therapy for breast cancer includes targeted therapies such
as endocrine therapy for estrogen receptor-alpha (ERα) positive; anti-HER2 monoclonal …

Phytoestrogens are plant derived compounds found in a wide variety of foods, most notably
soy. A litany of health benefits including a lowered risk of osteoporosis, heart disease, breast …

Estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ) belong to a superfamily of
nuclear receptors called steroid hormone receptors, which, upon binding ligand, dimerize …

In mammals, the effects of estrogen are mainly mediated by two different estrogen receptors,
ERα and ERβ. These proteins are members of the nuclear receptor family, characterized by …

Lipedema is a painful fat disorder that affects~ 11% of the female population. It is
characterized by bilateral, disproportionate accumulation of subcutaneous adipose tissue …

Estrogen is essential for growth and development of the mammary glands and has been
associated with the promotion and growth of breast cancer and in line with this, most human …

Colorectal cancer (CRC) is a leading cause of death in the United States. Despite its slow
development and the capacity for early diagnosis, current preventive approaches are not …