The antifungal pipeline: fosmanogepix, ibrexafungerp, olorofim, opelconazole, and rezafungin

M Hoenigl, R Sprute, M Egger, A Arastehfar… - Drugs, 2021 - Springer
The epidemiology of invasive fungal infections is changing, with new populations at risk and
the emergence of resistance caused by the selective pressure from increased usage of …

Fosmanogepix: a review of the first-in-class broad spectrum agent for the treatment of invasive fungal infections

KJ Shaw, AS Ibrahim - Journal of Fungi, 2020 - mdpi.com
Fosmanogepix is a first-in-class antifungal currently in Phase 2 clinical trials for the treatment
of invasive fungal infections caused by Candida, Aspergillus and rare molds. Fosmanogepix …

Invasive aspergillosis in solid‐organ transplant recipients: guidelines from the American Society of Transplantation Infectious Diseases Community of Practice

S Husain, JF Camargo - Clinical transplantation, 2019 - Wiley Online Library
These updated AST‐IDCOP guidelines provide information on epidemiology, diagnosis, and
management of Aspergillus after organ transplantation. Aspergillus is the most common …

Candidiasis: From cutaneous to systemic, new perspectives of potential targets and therapeutic strategies

H Lu, T Hong, Y Jiang, M Whiteway, S Zhang - Advanced Drug Delivery …, 2023 - Elsevier
Candidiasis is an infection caused by fungi from a Candida species, most commonly
Candida albicans. C. albicans is an opportunistic fungal pathogen typically residing on …

Pharmacodynamics, mechanisms of action and resistance, and spectrum of activity of new antifungal agents

NP Wiederhold - Journal of Fungi, 2022 - mdpi.com
Several new antifungals are currently in late-stage development, including those with novel
pharmacodynamics/mechanisms of action that represent new antifungal classes …

A comprehensive overview of the medicinal chemistry of antifungal drugs: perspectives and promise

KC Howard, EK Dennis, DS Watt… - Chemical Society …, 2020 - pubs.rsc.org
The emergence of new fungal pathogens makes the development of new antifungal drugs a
medical imperative that in recent years motivates the talents of numerous investigators …

Aspergillus fumigatus and aspergillosis: From basics to clinics

A Arastehfar, A Carvalho, J Houbraken… - Studies in …, 2021 - ingentaconnect.com
The airborne fungus Aspergillus fumigatus poses a serious health threat to humans by
causing numerous invasive infections and a notable mortality in humans, especially in …

[HTML][HTML] COVID-19-associated candidiasis and the emerging concern of Candida auris infections

CS Tsai, SSJ Lee, WC Chen, CH Tseng, NY Lee… - Journal of Microbiology …, 2023 - Elsevier
The incidence of COVID-19-associated candidiasis (CAC) is increasing, resulting in a grave
outcome among hospitalized patients with COVID-19. The most alarming condition is the …

Aspergillus fumigatus and pan-azole resistance: who should be concerned?

NP Wiederhold, PE Verweij - Current opinion in infectious …, 2020 - journals.lww.com
Azole-resistant A. fumigatus is an emerging threat that hampers our ability to successfully
treat patients with aspergillosis. Certain geographic regions and patient populations appear …

The combination treatment of fosmanogepix and liposomal amphotericin B is superior to monotherapy in treating experimental invasive mold infections

T Gebremariam, Y Gu, S Alkhazraji… - Antimicrobial Agents …, 2022 - Am Soc Microbiol
Invasive pulmonary aspergillosis (IPA), invasive mucormycosis (IM), and invasive fusariosis
(IF) are associated with high mortality and morbidity. Fosmanogepix (FMGX) is a first-in …