K Nuytemans, J Theuns, M Cruts… - Human …, 2010 - Wiley Online Library
To date, molecular genetic analyses have identified over 500 distinct DNA variants in five disease genes associated with familial Parkinson disease; α‐synuclein (SNCA), parkin …
IF Mata, WJ Wedemeyer, MJ Farrer, JP Taylor… - Trends in …, 2006 - cell.com
Parkinson's disease (PD) is the most common motor neurodegenerative disease. Mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2) have been linked recently with …
Although essential tremor (ET) and Parkinson's disease (PD) are considered distinct disorders, there is overlap in some clinical features. In some PD patients, a long-standing …
EK Tan, LM Skipper - Human mutation, 2007 - Wiley Online Library
Parkinson disease (PD; Parkinson's) is the second most common neurodegenerative disease, characterized by the progressive loss of dopamine neurons and the accumulation …
H Deng, W Le, J Jankovic - Brain, 2007 - academic.oup.com
Essential tremor (ET), the cause of which remains poorly understood, is one of the most common neurological disorders. While environmental agents have been proposed to play a …
R Fekete, J Jankovic - Movement Disorders, 2011 - Wiley Online Library
Background: The relationship between essential tremor and Parkinson's disease has been a subject of reviews and debates for long time, but there is now growing evidence that the two …
SY Lim, C Klein - Journal of Parkinson's Disease, 2024 - content.iospress.com
The discovery of a pathogenic variant in the alpha-synuclein (SNCA) gene in the Contursi kindred in 1997 indisputably confirmed a genetic cause in a subset of Parkinson's disease …
EK Tan, Y Zhao, L Skipper, MG Tan, A Di Fonzo, L Sun… - Human genetics, 2007 - Springer
Evidence of LRRK2 haplotypes associated with Parkinson's disease (PD) risk was recently found in the Chinese population from Singapore, and a common LRRK2 missense variant …