The role of viral infections in the onset of autoimmune diseases
B Sundaresan, F Shirafkan, K Ripperger, K Rattay - Viruses, 2023 - mdpi.com
Autoimmune diseases (AIDs) are the consequence of a breach in immune tolerance,
leading to the inability to sufficiently differentiate between self and non-self. Immune …
leading to the inability to sufficiently differentiate between self and non-self. Immune …
Abnormalities of T cells in systemic lupus erythematosus: new insights in pathogenesis and therapeutic strategies
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by loss of
immune tolerance and sustained production of autoantibodies. Multiple and profound T cell …
immune tolerance and sustained production of autoantibodies. Multiple and profound T cell …
Low-dose interleukin-2 treatment selectively modulates CD4+ T cell subsets in patients with systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is a potentially life-threatening autoimmune disease
characterized by altered balance of activity between effector and regulatory CD4+ T cells …
characterized by altered balance of activity between effector and regulatory CD4+ T cells …
Hydroxychloroquine in systemic lupus erythematosus (SLE)
C Ponticelli, G Moroni - Expert opinion on drug safety, 2017 - Taylor & Francis
Introduction: Hydroxychloroquine (HCQ) is an alkalinizing lysosomatropic drug that
accumulates in lysosomes where it inhibits some important functions by increasing the pH …
accumulates in lysosomes where it inhibits some important functions by increasing the pH …
Taming lupus—a new understanding of pathogenesis is leading to clinical advances
Z Liu, A Davidson - Nature medicine, 2012 - nature.com
Systemic lupus erythematosus (SLE) is an autoimmune disease that is characterized by the
loss of tolerance to nuclear self antigens, the production of pathogenic autoantibodies and …
loss of tolerance to nuclear self antigens, the production of pathogenic autoantibodies and …
Low-density granulocytes: a distinct class of neutrophils in systemic autoimmunity
C Carmona-Rivera, MJ Kaplan - Seminars in immunopathology, 2013 - Springer
Recent studies have renewed the interest on the potential role that neutrophils play in the
development of systemic lupus erythematosus (SLE) and other autoimmune conditions. A …
development of systemic lupus erythematosus (SLE) and other autoimmune conditions. A …
Peptidylarginine deiminase inhibition is immunomodulatory and vasculoprotective in murine lupus
Recent evidence suggests that enhanced neutrophil extracellular trap (NET) formation
activates plasmacytoid dendritic cells and serves as a source of autoantigens in SLE. We …
activates plasmacytoid dendritic cells and serves as a source of autoantigens in SLE. We …
The pathogenesis of systemic lupus erythematosus—an update
J Choi, ST Kim, J Craft - Current opinion in immunology, 2012 - Elsevier
Systemic lupus erythematosus (SLE, lupus) is characterized by a global loss of self-
tolerance with activation of autoreactive T and B cells leading to production of pathogenic …
tolerance with activation of autoreactive T and B cells leading to production of pathogenic …
Regulatory T cells in systemic lupus erythematosus
K Ohl, K Tenbrock - European journal of immunology, 2015 - Wiley Online Library
Systemic lupus erythematosus (SLE), an autoimmune disease, develops when immunologic
self‐tolerance fails. Treg cells are a subset of CD4+ T cells that maintain self‐tolerance by …
self‐tolerance fails. Treg cells are a subset of CD4+ T cells that maintain self‐tolerance by …
Neutrophils in the pathogenesis and manifestations of SLE
MJ Kaplan - Nature Reviews Rheumatology, 2011 - nature.com
Systemic lupus erythematosus (SLE) is an autoimmune disease of unclear etiology that
affects mostly women of childbearing age. Profound abnormalities in both innate and …
affects mostly women of childbearing age. Profound abnormalities in both innate and …