Twenty years of SynGAP research: from synapses to cognition
TR Gamache, Y Araki, RL Huganir - Journal of Neuroscience, 2020 - Soc Neuroscience
SynGAP is a potent regulator of biochemical signaling in neurons and plays critical roles in
neuronal function. It was first identified in 1998, and has since been extensively …
neuronal function. It was first identified in 1998, and has since been extensively …
Emerging roles of O-glycosylation in regulating protein aggregation, phase separation, and functions
Protein O-glycosylation is widely identified in various proteins involved in diverse biological
processes. Recent studies have demonstrated that O-glycosylation plays crucial and …
processes. Recent studies have demonstrated that O-glycosylation plays crucial and …
O-GlcNAcylation modulates liquid–liquid phase separation of SynGAP/PSD-95
Liquid–liquid phase separation (LLPS) of SynGAP and PSD-95, two abundant proteins that
interact in the postsynaptic density (PSD) of neurons, has been implicated in modulating …
interact in the postsynaptic density (PSD) of neurons, has been implicated in modulating …
Rapid dispersion of SynGAP from synaptic spines triggers AMPA receptor insertion and spine enlargement during LTP
Summary SynGAP is a Ras-GTPase activating protein highly enriched at excitatory
synapses in the brain. Previous studies have shown that CaMKII and the RAS-ERK pathway …
synapses in the brain. Previous studies have shown that CaMKII and the RAS-ERK pathway …
Differential roles of NR2A-and NR2B-containing NMDA receptors in Ras-ERK signaling and AMPA receptor trafficking
NMDA receptors (NMDARs) control bidirectional synaptic plasticity by regulating
postsynaptic AMPA receptors (AMPARs). Here we show that NMDAR activation can have …
postsynaptic AMPA receptors (AMPARs). Here we show that NMDAR activation can have …
Mutations in SYNGAP1 Cause Intellectual Disability, Autism, and a Specific Form of Epilepsy by Inducing Haploinsufficiency
De novo mutations in SYNGAP1, which codes for a RAS/RAP GTP‐activating protein, cause
nonsyndromic intellectual disability (NSID). All disease‐causing point mutations identified …
nonsyndromic intellectual disability (NSID). All disease‐causing point mutations identified …
[HTML][HTML] Mutations in SYNGAP1 in Autosomal Nonsyndromic Mental Retardation
FF Hamdan, J Gauthier, D Spiegelman… - … England Journal of …, 2009 - Mass Medical Soc
Although autosomal forms of nonsyndromic mental retardation account for the majority of
cases of mental retardation, the genes that are involved remain largely unknown. We …
cases of mental retardation, the genes that are involved remain largely unknown. We …
SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation
G Krapivinsky, I Medina, L Krapivinsky, S Gapon… - Neuron, 2004 - cell.com
The synapse contains densely localized and interacting proteins that enable it to adapt to
changing inputs. We describe a Ca 2+-sensitive protein complex involved in the regulation …
changing inputs. We describe a Ca 2+-sensitive protein complex involved in the regulation …
De novo SYNGAP1 mutations in nonsyndromic intellectual disability and autism
BACKGROUND: Little is known about the genetics of nonsyndromic intellectual disability
(NSID). Recently, we reported de novo truncating mutations in the SYNGAP1 gene of 3 of 94 …
(NSID). Recently, we reported de novo truncating mutations in the SYNGAP1 gene of 3 of 94 …
The role of synaptic GTPase-activating protein in neuronal development and synaptic plasticity
JH Kim, HK Lee, K Takamiya… - Journal of …, 2003 - Soc Neuroscience
Synaptic GTPase-activating protein (SynGAP) is a neuronal RasGAP (Ras GTPase-
activating protein) that is selectively expressed in brain and highly enriched at excitatory …
activating protein) that is selectively expressed in brain and highly enriched at excitatory …