Change in MRI-PDFF and histologic response in patients with nonalcoholic steatohepatitis: a systematic review and meta-analysis

JG Stine, N Munaganuru, A Barnard, JL Wang… - Clinical …, 2021 - Elsevier
Background & Aims Magnetic resonance imaging proton density fat fraction (MRI-PDFF)
offers promise as a non-invasive biomarker of treatment response in early-phase …

Pharmacotherapy for NASH: current and emerging

MA Konerman, JC Jones, SA Harrison - Journal of hepatology, 2018 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) has become one of the most prominent forms of
chronic liver disease worldwide, reflecting the epidemic of global obesity. Those with the …

Mortality due to cirrhosis and liver cancer in the United States, 1999-2016: observational study

EB Tapper, ND Parikh - bmj, 2018 - bmj.com
Objective To describe liver disease related mortality in the United States during 1999-2016
by age group, sex, race, cause of liver disease, and geographic region. Design …

Nonalcoholic steatohepatitis is the fastest growing cause of hepatocellular carcinoma in liver transplant candidates

Z Younossi, M Stepanova, JP Ong, IM Jacobson… - Clinical …, 2019 - Elsevier
Background & Aims Although hepatitis B and C have been the main drivers of hepatocellular
carcinoma (HCC), nonalcoholic steatohepatitis (NASH) has recently become an important …

[HTML][HTML] Effects of belapectin, an inhibitor of galectin-3, in patients with nonalcoholic steatohepatitis with cirrhosis and portal hypertension

N Chalasani, MF Abdelmalek, G Garcia-Tsao… - Gastroenterology, 2020 - Elsevier
Background & Aims Increased levels of galectin 3 have been associated with nonalcoholic
steatohepatitis (NASH) and contribute to toxin-induced liver fibrosis in mice. GR-MD-02 …

Risk prediction models for post‐operative mortality in patients with cirrhosis

N Mahmud, Z Fricker, RA Hubbard, GN Ioannou… - …, 2021 - Wiley Online Library
Background and Aims Patients with cirrhosis are at increased risk of postoperative mortality.
Currently available tools to predict postoperative risk are suboptimally calibrated and do not …

Randomized placebo-controlled trial of emricasan for non-alcoholic steatohepatitis-related cirrhosis with severe portal hypertension

G Garcia-Tsao, J Bosch, Z Kayali, SA Harrison… - Journal of …, 2020 - Elsevier
Background & Aims Emricasan, an oral pan-caspase inhibitor, decreased portal pressure in
experimental cirrhosis and in an open-label study in patients with cirrhosis and severe portal …

The global burden of HIV and prospects for control

A Pandey, AP Galvani - The Lancet HIV, 2019 - thelancet.com
Comment e810 www. thelancet. com/hiv Vol 6 December 2019 led to an increase in people
living with HIV from 8· 74 million in 1990 to 36· 82 million in 2017. Young adults remain at …

Nonalcoholic fatty liver disease cirrhosis: a review of its epidemiology, risk factors, clinical presentation, diagnosis, management, and prognosis

B Li, C Zhang, YT Zhan - Canadian Journal of Gastroenterology …, 2018 - Wiley Online Library
Cirrhosis is the common end stage of a number of chronic liver conditions and a significant
cause of morbidity and mortality. With the growing epidemic of obesity and metabolic …

Hepatocellular carcinoma tumour volume doubling time: a systematic review and meta-analysis

P Nathani, P Gopal, N Rich, A Yopp, T Yokoo, B John… - Gut, 2021 - gut.bmj.com
Background Tumour growth patterns have important implications for surveillance intervals,
prognostication and treatment decisions but have not been well described for hepatocellular …