The spectrum of inflammatory responses

R Medzhitov - Science, 2021 - science.org
Inflammation is an integral part of animal biology. It provides critical protection from adverse
environmental factors by enforcing the defense of homeostasis and the functional and …

IL-6 in inflammation, autoimmunity and cancer

T Hirano - International immunology, 2021 - academic.oup.com
IL-6 is involved both in immune responses and in inflammation, hematopoiesis, bone
metabolism and embryonic development. IL-6 plays roles in chronic inflammation (closely …

The enteric nervous system relays psychological stress to intestinal inflammation

KM Schneider, N Blank, Y Alvarez, K Thum… - Cell, 2023 - cell.com
Mental health profoundly impacts inflammatory responses in the body. This is particularly
apparent in inflammatory bowel disease (IBD), in which psychological stress is associated …

Brain motor and fear circuits regulate leukocytes during acute stress

WC Poller, J Downey, AA Mooslechner, N Khan, L Li… - Nature, 2022 - nature.com
The nervous and immune systems are intricately linked. Although psychological stress is
known to modulate immune function, mechanistic pathways linking stress networks in the …

[HTML][HTML] Guts imbalance imbalances the brain: a review of gut microbiota association with neurological and psychiatric disorders

L Mitrea, SA Nemeş, K Szabo, BE Teleky… - Frontiers in …, 2022 - frontiersin.org
In the last ten years, there has been a growing interest regarding the relationship between
gut microbiota, brain, and neurological-associated affections. As multiple preclinical and …

Tissue homeostasis and inflammation

ML Meizlish, RA Franklin, X Zhou… - Annual review of …, 2021 - annualreviews.org
There is a growing interest in understanding tissue organization, homeostasis, and
inflammation. However, despite an abundance of data, the organizing principles of tissue …

Integrated cytokine and metabolite analysis reveals immunometabolic reprogramming in COVID-19 patients with therapeutic implications

N Xiao, M Nie, H Pang, B Wang, J Hu, X Meng… - Nature …, 2021 - nature.com
Cytokine release syndrome (CRS) is a major cause of the multi-organ injury and fatal
outcome induced by SARS-CoV-2 infection in severe COVID-19 patients. Metabolism can …

Metabolic orchestration of the wound healing response

SA Eming, PJ Murray, EJ Pearce - Cell metabolism, 2021 - cell.com
Wound healing requires cooperation between different cell types, among which
macrophages play a central role. In particular, inflammatory macrophages are engaged in …

The evolving view of thermogenic adipocytes—ontogeny, niche and function

F Shamsi, CH Wang, YH Tseng - Nature Reviews Endocrinology, 2021 - nature.com
The worldwide incidence of obesity and its sequelae, such as type 2 diabetes mellitus, have
reached pandemic levels. Central to the development of these metabolic disorders is …

Hypoxic glioma-derived exosomes promote M2-like macrophage polarization by enhancing autophagy induction

J Xu, J Zhang, Z Zhang, Z Gao, Y Qi, W Qiu, Z Pan… - Cell Death & …, 2021 - nature.com
Exosomes participate in intercellular communication and glioma microenvironment
modulation, but the exact mechanisms by which glioma-derived exosomes (GDEs) promote …