Systemic drug delivery methods such as oral or parenteral administration of free drugs
possess relatively low treatment efficiency and marked adverse side effects. The use of …

This review summarizes the research on phospholipids and their use for drug delivery
related to the Phospholipid Research Center Heidelberg (PRC). The focus is on projects that …

The skin is the largest organ of the body, whose main function is to protect the body against
the loss of physiologically important components as well as harmful environmental insults …

The outer most layer of the skin, the stratum corneum, consists of corneocytes which are
coated by a cornified envelope and embedded in a lipid matrix of ordered lamellar structure …

The purpose of the current research was to prepare and evaluate the potential use of
microemulsion-based hydrogel (MBH) formulations for dermal delivery of benzocaine (BZN) …

The objective of this work was to prepare an oil/water glimepiride (GM) microemulsion (ME)
for oral administration to improve its solubility and enhance its bioavailability. Based on a …

Terconazole (Tr) is the first marketed, most active triazole for vaginal candidiasis. Owing to
poor skin permeation and challenging physicochemical properties, Tr was not employed for …

To elaborate the decisive role of surfactants in promotion of aceclofenac'skin absorption,
potentially avoiding irritation, we developed non-ionic microemulsions varying natural or …

Due to the lipophilic properties of the uppermost skin layer of the stratum corneum (SC) it is
highly challenging to reach therapeutic concentrations of cosmetic actives and drugs …

Deficiency or altered composition of stratum corneum (SC) lipids such as ceramides (CERs),
causing skin barrier dysfunction and skin dryness, have been associated with skin diseases …