The present review describes the morphological, phytochemical and ethnopharmacological
aspects of Humulus lupulus L.(Cannabinaceae) and summarizes the most interesting …

The regulation of the circadian rhythm is relayed from the central nervous system to the
periphery by melatonin, a hormone synthesized at night in the pineal gland. Besides two …

Ramelteon (TAK-375) is a novel melatonin receptor agonist currently under investigation for
the treatment of insomnia. This study describes the neurochemical and receptor binding …

Melatonin and melatonin isomers exist and/or coexist in living organisms including yeasts,
bacteria and plants. The levels of melatonin isomers are significantly higher than that of …

There is now evidence for more than one site of action for the hormone melatonin (N-acetyl-
5-methoxytryptamine). Recent pharmacological and molecular advances are providing the …

Melatonin, an indoleamine neurohormone that is synthesized mainly in the pineal gland and
derived from 5-HT, has many effects on a wide range of physio-pathological functions. Some …

Literature is reviewed indicating that aging is characterized by changes in circadian rhythms
and sleep quality. The most marked change is an attenuation of amplitude. An advance of …

The neurohormone melatonin is the central switch of the circadian rhythm and presumably
exerts its activities through a series of receptors among which MT1 and MT2 have been …

Acuna‐Costroviejo D, Reiter RJ, Menéndez‐Peláez A, Pablos MI, Burgos A.
Characterization of high‐affinity melatonin binding sites in purified cell nuclei of rat liver. J …

Periventricular leukomalacia is one of the main causes of cerebral palsy. Perinatal white
matter lesions associated with cerebral palsy appears to involve glutamate excitotoxicity and …