Sirtuin 3–dependent mitochondrial dynamic improvements protect against acute kidney injury
Acute kidney injury (AKI) is a public health concern with an annual mortality rate that
exceeds those of breast and prostate cancer, heart failure, and diabetes combined …
exceeds those of breast and prostate cancer, heart failure, and diabetes combined …
Mechanisms underlying the anti-wasting effect of l-carnitine supplementation under pathologic conditions: evidence from experimental and clinical studies
R Ringseis, J Keller, K Eder - European journal of nutrition, 2013 - Springer
Purpose Loss of skeletal muscle mass, also known as muscle wasting or muscle atrophy, is
a common symptom of several chronic diseases, such as cancer and infectious diseases …
a common symptom of several chronic diseases, such as cancer and infectious diseases …
The effect of L-carnitine on critical illnesses such as traumatic brain injury (TBI), acute kidney injury (AKI), and hyperammonemia (HA)
B Sharma, L Schmidt, C Nguyen, S Kiernan… - Metabolites, 2024 - mdpi.com
L-carnitine (LC) through diet is highly beneficial for critical patients. Studies have found that
acetyl-L-carnitine (ALC) can reduce cerebral edema and neurological complications in TBI …
acetyl-L-carnitine (ALC) can reduce cerebral edema and neurological complications in TBI …
Mechanism of cisplatin proximal tubule toxicity revealed by integrating transcriptomics, proteomics, metabolomics and biokinetics
Cisplatin is one of the most widely used chemotherapeutic agents for the treatment of solid
tumours. The major dose-limiting factor is nephrotoxicity, in particular in the proximal tubule …
tumours. The major dose-limiting factor is nephrotoxicity, in particular in the proximal tubule …
Precise monitoring of drug-induced kidney injury using an endoplasmic reticulum-targetable ratiometric time-gated luminescence probe for superoxide anions
Z Tang, B Song, W Zhang, L Guo, J Yuan - Analytical chemistry, 2019 - ACS Publications
Drug-induced acute kidney injury (AKI), caused by renal drug metabolism, has been
considered to be a major barrier in drug development and clinical treatment. Among various …
considered to be a major barrier in drug development and clinical treatment. Among various …
Acetyl-L-carnitine treatment following spinal cord injury improves mitochondrial function correlated with remarkable tissue sparing and functional recovery
SP Patel, PG Sullivan, TS Lyttle, DSK Magnuson… - Neuroscience, 2012 - Elsevier
We have recently documented that treatment with the alternative biofuel, acetyl-l-carnitine
(ALC, 300 mg/kg), as late as 1 h after T10 contusion spinal cord injury (SCI), significantly …
(ALC, 300 mg/kg), as late as 1 h after T10 contusion spinal cord injury (SCI), significantly …
Aged garlic extract protects against oxidative stress and renal changes in cisplatin-treated adult male rats
AY Nasr, HAM Saleh - Cancer cell international, 2014 - Springer
Background Cisplatin (CP) is one of the effective anticancer drugs, but it causes many side
effects. Aged garlic extract (AGE) is a natural herbal product used in management of many …
effects. Aged garlic extract (AGE) is a natural herbal product used in management of many …
Antioxidant effect of acetyl-l-carnitine against cisplatin-induced cardiotoxicity
Objective Cisplatin (CDDP) toxicity is a dose-limiting clinical problem in clinical practice,
mainly because of nephrotoxicity or ototoxicity. However, the mechanism of CDDP-induced …
mainly because of nephrotoxicity or ototoxicity. However, the mechanism of CDDP-induced …
Comparison of 3-and 6-month outcomes of combined oral L-carnitine fumarate and acetyl-L-carnitine therapy, included in an antioxidant formulation, in patients with …
M Szymański, T Wandtke, K Wasilow… - American Journal of …, 2021 - journals.sagepub.com
The male factor is responsible for infertility in about 35–40% of all cases. Idiopathic oligo-
and/or astheno-and/or therato-zoospermia is one of the most common male fertility disorders …
and/or astheno-and/or therato-zoospermia is one of the most common male fertility disorders …
Nephroprotective potential of carnitine against glycerol and contrast-induced kidney injury in rats through modulation of oxidative stress, proinflammatory cytokines …
Objective: Contrast media (CM) are a major cause of nephropathy in high-risk patients. The
aim of this study was to examine the effects of carnitine (CAR) in advanced nephrotoxicity …
aim of this study was to examine the effects of carnitine (CAR) in advanced nephrotoxicity …