Breast cancer is associated with the second highest cancer-associated deaths worldwide.
Therefore, understanding the key events that determine breast cancer progression …

Metastases, rather than primary tumours, are responsible for most cancer deaths. To prevent
these deaths, improved ways to treat metastatic disease are needed. Blood flow and other …

Despite recognizing the devastating consequences of metastasis, we are not yet able to
effectively treat cancer that has spread to vital organs. The inherent complexity of genomic …

Tumour heterogeneity poses a substantial problem for the clinical management of cancer.
Somatic evolution of the cancer genome results in genetically distinct subclones in the …

Tumour metastasis is a significant contributor to death in cancer patients. Eight metastasis-
suppressor genes that reduce the metastatic propensity of a cancer cell line in vivo without …

Oncogenesis and tumour progression are supported by alterations in cell signalling. Using
flow cytometry, it is now possible to track and analyse signalling events in individual cancer …

Mouse models of human cancer have played a vital role in understanding tumorigenesis
and answering experimental questions that other systems cannot address. Advances …

The small DNA tumor viruses have provided a very long-lived source of insights into many
aspects of the life cycle of eukaryotic cells. In recent years, the emphasis has been on …

Previous work identified the Rap1 GTPase-activating protein Sipa1 as a germ-line-encoded
metastasis modifier. The bromodomain protein Brd4 physically interacts with and modulates …

Breast cancer metastasis suppressor 1 (BRMS1) suppresses metastasis of multiple human
and murine cancer cells without inhibiting tumorigenicity. By yeast two-hybrid and co …