In humans, the S100 protein family is composed of 21 members that exhibit a high degree of
structural similarity, but are not functionally interchangeable. This family of proteins …

The S100 protein family consists of 24 members functionally distributed into three main
subgroups: those that only exert intracellular regulatory effects, those with intracellular and …

The widely used CHARMM additive all‐atom force field includes parameters for proteins,
nucleic acids, lipids, and carbohydrates. In the present article, an extension of the CHARMM …

Protein–protein interactions (PPIs) control the assembly of multi-protein complexes and,
thus, these contacts have enormous potential as drug targets. However, the field has …

J. Neurochem.(2012) 120, 644–659. Abstract S100B is a calcium‐binding protein
concentrated in glial cells, although it has also been detected in definite extra‐neural cell …

S100 proteins are widely expressed small molecular EF-hand calcium-binding proteins of
vertebrates, which are involved in numerous cellular processes, such as Ca2+ homeostasis …

The BCL6 transcriptional repressor is the most frequently involved oncogene in diffuse large
B cell lymphoma (DLBCL). We combined computer-aided drug design with functional …

Toll-like receptor (TLR) signaling is initiated by dimerization of intracellular Toll/IL-1 receptor
resistance (TIR) domains. For all TLRs except TLR3, recruitment of the adapter, myeloid …

S100B belongs to a multigenic family of Ca2+‐binding proteins of the EF‐hand type and is
expressed in high abundance in the brain. S100B interacts with target proteins within cells …

Protein‐protein interactions (PPIs) are closely implicated in various types of cellular activities
and are thus pivotal to health and disease states. Given their fundamental roles in a wide …