Oncogene activation disturbs cellular processes and accommodates a complex landscape
of changes in the genome that contribute to genomic instability, which accelerates mutation …

R loops are three-stranded nucleic acid structures that comprise nascent RNA hybridized
with the DNA template, leaving the nontemplate DNA single-stranded. R loops form naturally …

RNA: DNA hybrid structures known as R loops were thought to be rare byproducts of
transcription. In the last decade, however, accumulating evidence has pointed to a new view …

Genome replication involves dealing with obstacles that can result from DNA damage but
also from chromatin alterations, topological stress, tightly bound proteins or non-B DNA …

Mitochondria play a central role in cellular energy provision. The organelles contain their
own genome with a modified genetic code. The mammalian mitochondrial genome is …

Given the tiny size of the mammalian mitochondrial genome, at only 16.5 kb, it is often
surprising how little we know about some of its molecular features, and the molecular …

Genome integrity relies on the accuracy of DNA metabolism, but as appreciated for more
than four decades, transcription enhances mutation and recombination frequencies. More …

The discovery that mutations in mitochondrial DNA (mtDNA) can be pathogenic in humans
has increased interest in understanding mtDNA maintenance. The functional state of mtDNA …

The mitochondrion was originally a free-living prokaryotic organism, which explains the
presence of a compact mammalian mitochondrial DNA (mtDNA) in contempory mammalian …

RNA/DNA hybrids form when RNA hybridizes with its template DNA generating a three-
stranded structure known as the R-loop. Knowledge of how they form and resolve, as well as …